Featured Publications
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization
Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J. Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature 2010, 465: 478-482. PMID: 20505729, PMCID: PMC2879083, DOI: 10.1038/nature09001.Peer-Reviewed Original ResearchConceptsAge-related cognitive disordersBlood vesselsPossible therapeutic targetAged miceBlood flowTherapeutic targetCognitive disordersMice showBlood clotsEndothelial cellsUnderlying endotheliumMicroemboliExtravasationFibrinolysisVesselsRecanalizationEmboliPatientsStrokeEndotheliumMiceBloodBrainWeeksClots
2001
Cholinesterase Inhibitors for Alzheimer’s Disease
Grutzendler J, Morris J. Cholinesterase Inhibitors for Alzheimer’s Disease. Drugs 2001, 61: 41-52. PMID: 11217870, DOI: 10.2165/00003495-200161010-00005.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCholinesterase inhibitorsCommon age-related neurodegenerative diseaseDifferent safety profilesAvailability of acetylcholineUrgent public health problemAge-related neurodegenerative diseasesModerate Alzheimer's diseasePublic health problemPossible adverse effectsPrimary therapySymptomatic treatmentSafety profileChEIsCentral synapsesClinical experienceUS FoodDrug AdministrationHealth problemsBasic neurobiologyCognitive statusNeurodegenerative diseasesPatientsDiseaseAdverse effects