2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Li J, Conrad C, Mills T, Berg N, Kim B, Ruan W, Lee J, Zhang X, Yuan X, Eltzschig H. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. Journal Of Experimental Medicine 2021, 218: e20210008. PMID: 33891683, PMCID: PMC8077173, DOI: 10.1084/jem.20210008.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMyocardial ischemia-reperfusion injuryNetrin-1Cardiac ischemia-reperfusion injuryNetrin-1 levelsGuidance molecule netrin-1Blood of patientsAdenosine A2B receptorTissue-specific sourceRecombinant netrin-1Adenosine A2BNeutrophil depletionTroponin levelsIschemic insultInfarct sizeMyocardial injuryMyocardial infarctionTissue injuryPharmacologic studiesFunctional roleA2B receptorsInjuryVivo studiesMiceTissue compartments
2020
Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion.
Lee J, Koeppen M, Seo S, Bowser J, Yuan X, Li J, Sibilia M, Ambardekar A, Zhang X, Eckle T, Yoo S, Eltzschig H. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology 2020, 132: 763-780. PMID: 31794514, PMCID: PMC7072004, DOI: 10.1097/aln.0000000000003037.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor 2AReperfusion injuryMyocardial ischemiaErbB1 expressionTranscription-independent inductionGrowth factorEpidermal growth factorFactor 2AIschemic heart disease patientsMyocardial tissueRole of ErbB1Larger infarct sizeIschemic heart diseaseHeart disease patientsNormal control patientsReceptor 1 expressionMyocardial ischemia toleranceHypoxia-inducible factorHuman myocardial tissueControl patientsInfarct sizeDisease patientsHeart diseaseIschemiaKnockout mice
2019
Hypoxia signaling in human diseases and therapeutic targets
Lee J, Ko J, Ju C, Eltzschig H. Hypoxia signaling in human diseases and therapeutic targets. Experimental & Molecular Medicine 2019, 51: 1-13. PMID: 31221962, PMCID: PMC6586801, DOI: 10.1038/s12276-019-0235-1.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorNovel therapeutic optionsChronic disease conditionsDifferent organ systemsDownstream targetsOrgan injuryTherapeutic optionsTherapeutic targetOrgan systemsHIF stabilizationHypoxiaDisease conditionsClinical medicineCurrent knowledgeHuman diseasesDivergent rolesNumerous studiesCurrent understandingLungInjuryTargetKidneyPathwayDiseaseLiver
2018
MicroRNA miR-223 as regulator of innate immunity
Yuan X, Berg N, Lee J, Le T, Neudecker V, Jing N, Eltzschig H. MicroRNA miR-223 as regulator of innate immunity. Journal Of Leukocyte Biology 2018, 104: 515-524. PMID: 29969525, PMCID: PMC6638550, DOI: 10.1002/jlb.3mr0218-079r.Peer-Reviewed Original ResearchConceptsExcessive innate immune responseInnate immune responseInflammatory diseasesMiR-223Immune responseMyeloid cellsAcute respiratory distress syndromeInflammatory bowel diseaseRespiratory distress syndromeMyeloid cell homeostasisMacrophage differentiationMyeloid differentiationMyeloid activationMiR-223 contributesMucosal inflammationBowel diseaseDistress syndromeInflammatory targetsMacrophage functionPotential treatmentInnate immunityTherapeutic enhancementDiseaseNegative feedback mechanismKey modulatorHypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, Buttrick P, Eckle T, Eltzschig H. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nature Communications 2018, 9: 816. PMID: 29483579, PMCID: PMC5827027, DOI: 10.1038/s41467-018-03105-2.Peer-Reviewed Original ResearchMeSH KeywordsAmphiregulinAnimalsBasic Helix-Loop-Helix Transcription FactorsCell LineGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitIntegrasesMaleMiceMice, TransgenicMicroarray AnalysisMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacMyosinsRNA, Small InterferingSignal TransductionConceptsMyocardial ischemia-reperfusion injuryIschemia-reperfusion injuryHypoxia-inducible factorHIF2 alphaCardiac myocytesIschemic heart diseaseGrowth factor amphiregulinMyocardial ischemia toleranceTranscription factor hypoxia-inducible factorHuman cardiac myocytesAreg deficiencyMyocardial inductionElicit cardioprotectionAREG expressionHeart diseaseHIF1 alphaPharmacologic inhibitionIschemia toleranceAmphiregulinCardioprotectionMyocardial tissueInducible deletionMyocytesInjuryMiceTargeting Hypoxia Signaling for Perioperative Organ Injury
Yuan X, Lee J, Bowser J, Neudecker V, Sridhar S, Eltzschig H. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesthesia & Analgesia 2018, 126: 308-321. PMID: 28759485, PMCID: PMC5735013, DOI: 10.1213/ane.0000000000002288.Peer-Reviewed Original ResearchConceptsPerioperative organ injuryHypoxia-inducible factorOrgan injurySurgical patientsHIF target genesAcute respiratory distress syndromeRespiratory distress syndromePrevention of ischemiaCurrent therapeutic strategiesNovel pharmacologic strategiesOrgan injury modelsStabilization of HIFPotential clinical approachAcute kidneyGut injuryDistress syndromeReperfusion injuryAnemia treatmentPharmacologic strategiesSurgical outcomesOrgan protectionMyocardial infarctionInjury modelLeading causeTherapeutic strategies
2017
The hypoxia-adenosine link during inflammation
Bowser J, Lee J, Yuan X, Eltzschig H. The hypoxia-adenosine link during inflammation. Journal Of Applied Physiology 2017, 123: 1303-1320. PMID: 28798196, PMCID: PMC5792095, DOI: 10.1152/japplphysiol.00101.2017.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorInflammatory diseasesAdenosine metabolismAcute lung injuryInflammatory bowel diseaseExtracellular adenosine metabolismFuture treatment approachesLung injuryBowel diseaseMyocardial injuryProinflammatory responseInflammatory conditionsTissue protectionTreatment approachesInflammationTissue conditionsDiseaseHypoxic conditionsDirect targetInjuryHypoxiaTissue integrityMetabolismPatients