Targeting Hypoxia Signaling for Perioperative Organ Injury
Yuan X, Lee J, Bowser J, Neudecker V, Sridhar S, Eltzschig H. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesthesia & Analgesia 2018, 126: 308-321. PMID: 28759485, PMCID: PMC5735013, DOI: 10.1213/ane.0000000000002288.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene TargetingHumansHypoxiaHypoxia-Inducible Factor 1Intraoperative ComplicationsMultiple Organ FailureSignal TransductionConceptsPerioperative organ injuryHypoxia-inducible factorOrgan injurySurgical patientsHIF target genesAcute respiratory distress syndromeRespiratory distress syndromePrevention of ischemiaCurrent therapeutic strategiesNovel pharmacologic strategiesOrgan injury modelsStabilization of HIFPotential clinical approachAcute kidneyGut injuryDistress syndromeReperfusion injuryAnemia treatmentPharmacologic strategiesSurgical outcomesOrgan protectionMyocardial infarctionInjury modelLeading causeTherapeutic strategies