2019
Hypoxia signaling in human diseases and therapeutic targets
Lee J, Ko J, Ju C, Eltzschig H. Hypoxia signaling in human diseases and therapeutic targets. Experimental & Molecular Medicine 2019, 51: 1-13. PMID: 31221962, PMCID: PMC6586801, DOI: 10.1038/s12276-019-0235-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHeart DiseasesHumansHypoxiaHypoxia-Inducible Factor 1Kidney DiseasesLiver DiseasesLung DiseasesSignal TransductionConceptsHypoxia-inducible factorNovel therapeutic optionsChronic disease conditionsDifferent organ systemsDownstream targetsOrgan injuryTherapeutic optionsTherapeutic targetOrgan systemsHIF stabilizationHypoxiaDisease conditionsClinical medicineCurrent knowledgeHuman diseasesDivergent rolesNumerous studiesCurrent understandingLungInjuryTargetKidneyPathwayDiseaseLiver
2017
The hypoxia-adenosine link during inflammation
Bowser J, Lee J, Yuan X, Eltzschig H. The hypoxia-adenosine link during inflammation. Journal Of Applied Physiology 2017, 123: 1303-1320. PMID: 28798196, PMCID: PMC5792095, DOI: 10.1152/japplphysiol.00101.2017.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorInflammatory diseasesAdenosine metabolismAcute lung injuryInflammatory bowel diseaseExtracellular adenosine metabolismFuture treatment approachesLung injuryBowel diseaseMyocardial injuryProinflammatory responseInflammatory conditionsTissue protectionTreatment approachesInflammationTissue conditionsDiseaseHypoxic conditionsDirect targetInjuryHypoxiaTissue integrityMetabolismPatients