PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Li J, Conrad C, Mills T, Berg N, Kim B, Ruan W, Lee J, Zhang X, Yuan X, Eltzschig H. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. Journal Of Experimental Medicine 2021, 218: e20210008. PMID: 33891683, PMCID: PMC8077173, DOI: 10.1084/jem.20210008.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMyocardial ischemia-reperfusion injuryNetrin-1Cardiac ischemia-reperfusion injuryNetrin-1 levelsGuidance molecule netrin-1Blood of patientsAdenosine A2B receptorTissue-specific sourceRecombinant netrin-1Adenosine A2BNeutrophil depletionTroponin levelsIschemic insultInfarct sizeMyocardial injuryMyocardial infarctionTissue injuryPharmacologic studiesFunctional roleA2B receptorsInjuryVivo studiesMiceTissue compartments