MicroRNA miR-223 as regulator of innate immunity
Yuan X, Berg N, Lee J, Le T, Neudecker V, Jing N, Eltzschig H. MicroRNA miR-223 as regulator of innate immunity. Journal Of Leukocyte Biology 2018, 104: 515-524. PMID: 29969525, PMCID: PMC6638550, DOI: 10.1002/jlb.3mr0218-079r.Peer-Reviewed Original ResearchConceptsExcessive innate immune responseInnate immune responseInflammatory diseasesMiR-223Immune responseMyeloid cellsAcute respiratory distress syndromeInflammatory bowel diseaseRespiratory distress syndromeMyeloid cell homeostasisMacrophage differentiationMyeloid differentiationMyeloid activationMiR-223 contributesMucosal inflammationBowel diseaseDistress syndromeInflammatory targetsMacrophage functionPotential treatmentInnate immunityTherapeutic enhancementDiseaseNegative feedback mechanismKey modulatorTargeting Hypoxia Signaling for Perioperative Organ Injury
Yuan X, Lee J, Bowser J, Neudecker V, Sridhar S, Eltzschig H. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesthesia & Analgesia 2018, 126: 308-321. PMID: 28759485, PMCID: PMC5735013, DOI: 10.1213/ane.0000000000002288.Peer-Reviewed Original ResearchConceptsPerioperative organ injuryHypoxia-inducible factorOrgan injurySurgical patientsHIF target genesAcute respiratory distress syndromeRespiratory distress syndromePrevention of ischemiaCurrent therapeutic strategiesNovel pharmacologic strategiesOrgan injury modelsStabilization of HIFPotential clinical approachAcute kidneyGut injuryDistress syndromeReperfusion injuryAnemia treatmentPharmacologic strategiesSurgical outcomesOrgan protectionMyocardial infarctionInjury modelLeading causeTherapeutic strategies