2019
Hypoxia signaling in human diseases and therapeutic targets
Lee J, Ko J, Ju C, Eltzschig H. Hypoxia signaling in human diseases and therapeutic targets. Experimental & Molecular Medicine 2019, 51: 1-13. PMID: 31221962, PMCID: PMC6586801, DOI: 10.1038/s12276-019-0235-1.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorNovel therapeutic optionsChronic disease conditionsDifferent organ systemsDownstream targetsOrgan injuryTherapeutic optionsTherapeutic targetOrgan systemsHIF stabilizationHypoxiaDisease conditionsClinical medicineCurrent knowledgeHuman diseasesDivergent rolesNumerous studiesCurrent understandingLungInjuryTargetKidneyPathwayDiseaseLiver
2018
Targeting Hypoxia Signaling for Perioperative Organ Injury
Yuan X, Lee J, Bowser J, Neudecker V, Sridhar S, Eltzschig H. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesthesia & Analgesia 2018, 126: 308-321. PMID: 28759485, PMCID: PMC5735013, DOI: 10.1213/ane.0000000000002288.Peer-Reviewed Original ResearchConceptsPerioperative organ injuryHypoxia-inducible factorOrgan injurySurgical patientsHIF target genesAcute respiratory distress syndromeRespiratory distress syndromePrevention of ischemiaCurrent therapeutic strategiesNovel pharmacologic strategiesOrgan injury modelsStabilization of HIFPotential clinical approachAcute kidneyGut injuryDistress syndromeReperfusion injuryAnemia treatmentPharmacologic strategiesSurgical outcomesOrgan protectionMyocardial infarctionInjury modelLeading causeTherapeutic strategies