2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Li J, Conrad C, Mills T, Berg N, Kim B, Ruan W, Lee J, Zhang X, Yuan X, Eltzschig H. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. Journal Of Experimental Medicine 2021, 218: e20210008. PMID: 33891683, PMCID: PMC8077173, DOI: 10.1084/jem.20210008.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMyocardial ischemia-reperfusion injuryNetrin-1Cardiac ischemia-reperfusion injuryNetrin-1 levelsGuidance molecule netrin-1Blood of patientsAdenosine A2B receptorTissue-specific sourceRecombinant netrin-1Adenosine A2BNeutrophil depletionTroponin levelsIschemic insultInfarct sizeMyocardial injuryMyocardial infarctionTissue injuryPharmacologic studiesFunctional roleA2B receptorsInjuryVivo studiesMiceTissue compartments
2018
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, Buttrick P, Eckle T, Eltzschig H. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nature Communications 2018, 9: 816. PMID: 29483579, PMCID: PMC5827027, DOI: 10.1038/s41467-018-03105-2.Peer-Reviewed Original ResearchMeSH KeywordsAmphiregulinAnimalsBasic Helix-Loop-Helix Transcription FactorsCell LineGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitIntegrasesMaleMiceMice, TransgenicMicroarray AnalysisMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacMyosinsRNA, Small InterferingSignal TransductionConceptsMyocardial ischemia-reperfusion injuryIschemia-reperfusion injuryHypoxia-inducible factorHIF2 alphaCardiac myocytesIschemic heart diseaseGrowth factor amphiregulinMyocardial ischemia toleranceTranscription factor hypoxia-inducible factorHuman cardiac myocytesAreg deficiencyMyocardial inductionElicit cardioprotectionAREG expressionHeart diseaseHIF1 alphaPharmacologic inhibitionIschemia toleranceAmphiregulinCardioprotectionMyocardial tissueInducible deletionMyocytesInjuryMice