2018
MicroRNA miR-223 as regulator of innate immunity
Yuan X, Berg N, Lee J, Le T, Neudecker V, Jing N, Eltzschig H. MicroRNA miR-223 as regulator of innate immunity. Journal Of Leukocyte Biology 2018, 104: 515-524. PMID: 29969525, PMCID: PMC6638550, DOI: 10.1002/jlb.3mr0218-079r.Peer-Reviewed Original ResearchConceptsExcessive innate immune responseInnate immune responseInflammatory diseasesMiR-223Immune responseMyeloid cellsAcute respiratory distress syndromeInflammatory bowel diseaseRespiratory distress syndromeMyeloid cell homeostasisMacrophage differentiationMyeloid differentiationMyeloid activationMiR-223 contributesMucosal inflammationBowel diseaseDistress syndromeInflammatory targetsMacrophage functionPotential treatmentInnate immunityTherapeutic enhancementDiseaseNegative feedback mechanismKey modulator
2017
The hypoxia-adenosine link during inflammation
Bowser J, Lee J, Yuan X, Eltzschig H. The hypoxia-adenosine link during inflammation. Journal Of Applied Physiology 2017, 123: 1303-1320. PMID: 28798196, PMCID: PMC5792095, DOI: 10.1152/japplphysiol.00101.2017.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorInflammatory diseasesAdenosine metabolismAcute lung injuryInflammatory bowel diseaseExtracellular adenosine metabolismFuture treatment approachesLung injuryBowel diseaseMyocardial injuryProinflammatory responseInflammatory conditionsTissue protectionTreatment approachesInflammationTissue conditionsDiseaseHypoxic conditionsDirect targetInjuryHypoxiaTissue integrityMetabolismPatients