Long-term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children With Neurogenic Detrusor Overactivity
Franco I, Hoebeke P, Dobremez E, Titanji W, Geib T, Jenkins B, Yushmanova I, Austin P. Long-term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children With Neurogenic Detrusor Overactivity. Journal Of Urology 2023, 209: 774-784. PMID: 36655470, DOI: 10.1097/ju.0000000000003157.Peer-Reviewed Original ResearchMeSH KeywordsAdultBotulinum Toxins, Type AChildDouble-Blind MethodHumansTreatment OutcomeUrinary Bladder, NeurogenicUrinary Bladder, OveractiveUrinary Tract InfectionsConceptsTreatment-emergent adverse eventsNeurogenic detrusor overactivityUrinary tract infectionAdverse eventsSingle-treatment studyDetrusor overactivityTract infectionsSafety profileCommon treatment-emergent adverse eventsSerious treatment-emergent adverse eventsUrinary tract infection rateSimilar safety profileClean intermittent catheterizationNew safety concernsLong-term safetyAutonomic dysreflexiaIntermittent catheterizationMedian durationOnabotulinumtoxinA treatmentDistant spreadDose groupPediatric dataRepeat treatmentRepeated TreatmentPatients