2020
Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection. Foot & Ankle International 2020, 42: 363-372. PMID: 33161780, PMCID: PMC7946706, DOI: 10.1177/1071100720965136.Peer-Reviewed Original ResearchConceptsFoot infectionsHost immune responseWound healing statusImmune responseHealing statusFoot ulcer patientsProspective comparative studyCulture-positive patientsCulture-negative patientsSpecific serum antibodiesDominant pathogenAnalysis of serumConventional bacterial cultureUlcer patientsMusculoskeletal infectionsSurgical interventionAntibody titersSerum antibodiesTherapeutic responseInfection diagnosisSpecies-specific immunoassaySurgeon's decisionCulture resultsInfectionLevel IIAdjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work
Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça‐Huber D, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers W, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC, Workgroup H. Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work. Journal Of Orthopaedic Research® 2020, 39: 227-239. PMID: 31997412, PMCID: PMC7390691, DOI: 10.1002/jor.24616.Peer-Reviewed Original ResearchConceptsAntibiotic-loaded bone cementMusculoskeletal infectionsLevel 1 evidenceRoutine laboratory testingMinimum biofilm eradication concentrationBone cementBiofilm eradication concentrationALBC useBiofilm-associated bacteriaOrthopedic infectionsClinical relevanceClinical practiceDrug AdministrationDrug susceptibilityLocal deliveryEradication concentrationInfectionAntibiotic resistanceCurrent useEfficacyVivo biofilmsLaboratory testingMicrobial colonizationPropose areasSubstantial lack
2019
What Is the Best Method to Differentiate Acute Charcot Foot From Acute Infection?
Heidari N, Oh I, Li Y, Vris A, Kwok I, Charalambous A, Rogero R. What Is the Best Method to Differentiate Acute Charcot Foot From Acute Infection? Foot & Ankle International 2019, 40: 39s-42s. PMID: 31322932, DOI: 10.1177/1071100719859892.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCharcot neuroarthropathyPresence of neuropathyAcute Charcot footAcute Charcot neuroarthropathyMultiple diagnostic criteriaLikelihood of infectionCharcot footAcute infectionPhysical examinationHistologic examinationDiagnostic criteriaUnclear casesResonance imagingSkin woundsInfectionBone specimensLaboratory testingExaminationNeuroarthropathyNeuropathyOsteomyelitisScintigraphyErythemaWhat Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)?
Heidari N, Oh I, Malagelada F. What Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)? Foot & Ankle International 2019, 40: 21s-22s. PMID: 31322963, DOI: 10.1177/1071100719859536.Peer-Reviewed Original ResearchConceptsTotal ankle arthroplastySinus tractJoint aspirationInfected Total Ankle ArthroplastyElevated inflammatory markersSynovial fluid analysisAnkle infectionInflammatory markersOperative interventionArthroplasty infectionClinical symptomsAnkle arthroplastyHistologic examinationSubtalar jointRepeat aspirationSynovial fluidCell countFluid analysisPatientsInfectionNuclear imagingFurther investigationTractAspirationArthroplasty
2018
Tracking Anti-Staphylococcus aureus Antibodies Produced In Vivo and Ex Vivo during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity
Oh I, Muthukrishnan G, Ninomiya MJ, Brodell JD, Smith BL, Lee CC, Gill SR, Beck CA, Schwarz EM, Daiss JL. Tracking Anti-Staphylococcus aureus Antibodies Produced In Vivo and Ex Vivo during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity. Infection And Immunity 2018, 86: 10.1128/iai.00629-18. PMID: 30275008, PMCID: PMC6246899, DOI: 10.1128/iai.00629-18.Peer-Reviewed Original ResearchConceptsDiabetic foot infectionsIgG levelsDFI patientsSalvage therapyFoot infectionsCultured peripheral blood mononuclear cellsPeripheral blood mononuclear cellsBlood mononuclear cellsSimilar diagnostic potentialAggressive treatmentAntibody titersHumoral immunityMononuclear cellsPrognostic insightsPrognostic potentialCommon pathogensEtiologic agentMultivariate analysisClinical decisionEx vivoMultiplex immunoassayWound samplesInfectionSerumAureus antibody