PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long A, Brown J, Nunes R, Greenfield E, Bourque K, Boussiotis V, Carter L, Carreno B, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe A, Freeman G. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology 2001, 2: 261-268. PMID: 11224527, DOI: 10.1038/85330.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, CDAntigens, SurfaceApoptosisApoptosis Regulatory ProteinsB7-1 AntigenB7-H1 AntigenBlood ProteinsCD28 AntigensCells, CulturedCHO CellsCricetinaeCytokinesHumansIntercellular Signaling Peptides and ProteinsJurkat CellsLigandsLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMolecular Sequence DataPeptidesProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellSequence Homology, Amino AcidT-LymphocytesTransfectionConceptsPD-1 ligand 2PD-1 interactionPD-1PD-L1Cytokine productionAntigen concentrationPD-L expressionAutoimmune-like diseaseT cell responsesAntigen-presenting cellsT cell proliferationHigh antigen concentrationsT cell activationT cell receptorInterferon γ treatmentLow antigen concentrationsG0/G1Death-1Immunoinhibitory receptorCell cycle arrestDeficient miceT cellsCell activationΓ treatmentCell responses