2023
Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection.
Song W, Sanchez G, Mayer D, Blackburn H, Chernova I, Flavell R, Weinstein J, Craft J. Cutting Edge: IL-21 and Tissue-Specific Signals Instruct Tbet+CD11c+ B Cell Development following Viral Infection. The Journal Of Immunology 2023, 210: 1861-1865. PMID: 37133336, PMCID: PMC10247523, DOI: 10.4049/jimmunol.2300027.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationInterleukinsLymphocytic ChoriomeningitisMiceMice, Inbred C57BLMice, KnockoutConceptsAge-associated B cellsIL-21Acute lymphocytic choriomeningitis virus infectionB cellsLymphocytic choriomeningitis virus infectionB cell activationHumoral immunityLymphoid organsVirus infectionMouse modelViral infectionB cell developmentCell activationLymphotoxin αVivo generationTissue-specific signalsInfectionDe novo generationOrgan contributionIFNTissue microenvironmentCell developmentLiverPivotal contributorStage-specific roles
2022
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers
Song W, Antao OQ, Condiff E, Sanchez GM, Chernova I, Zembrzuski K, Steach H, Rubtsova K, Angeletti D, Lemenze A, Laidlaw BJ, Craft J, Weinstein JS. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity 2022, 55: 290-307.e5. PMID: 35090581, PMCID: PMC8965751, DOI: 10.1016/j.immuni.2022.01.002.Peer-Reviewed Original ResearchConceptsFollicular helper cellsB cellsGC B cellsHelper cellsMemory subsetsRobust recall responsesB cell subsetsGerminal center formationB cell generationAcute infectionCell subsetsRecall responsesTh1 cellsProximal deliveryCD11cGerminal centersIntegrin LFA-1Viral infectionAntibody productionVLA-4Splenic retentionLFA-1TbetBCL6 expressionInfection
2016
mTOR has distinct functions in generating versus sustaining humoral immunity
Jones DD, Gaudette BT, Wilmore JR, Chernova I, Bortnick A, Weiss BM, Allman D. mTOR has distinct functions in generating versus sustaining humoral immunity. Journal Of Clinical Investigation 2016, 126: 4250-4261. PMID: 27760048, PMCID: PMC5096901, DOI: 10.1172/jci86504.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntibody FormationCell DifferentiationEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsImmunity, HumoralMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMultiprotein ComplexesPlasma CellsRegulatory-Associated Protein of mTORSignal TransductionTOR Serine-Threonine KinasesConceptsPlasma cellsBone marrow plasma cellsAntibody-associated diseaseSystemic lupus erythematosusMarrow plasma cellsAntibody-secreting plasma cellsPlasma cell differentiationLineage-specific deletionRole of mTORLupus erythematosusAcute treatmentExogenous antigensHumoral immunityAntibody responseSerum antibodiesMurine modelAntibody synthesisGerminal centersBone marrowCell differentiationMTOR inhibitionRobust protein synthesisMTOR activityRapamycin treatmentMTOR complex 1
2012
Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens
Bortnick A, Chernova I, Quinn WJ, Mugnier M, Cancro MP, Allman D. Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens. The Journal Of Immunology 2012, 188: 5389-5396. PMID: 22529295, PMCID: PMC4341991, DOI: 10.4049/jimmunol.1102808.Peer-Reviewed Original Research