2013
Defining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432)
Yoo S, You S, Shin M, Lee N, Kang K, Hwang D, Kang I. Defining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432). The Journal Of Immunology 2013, 190: 117.16-117.16. DOI: 10.4049/jimmunol.190.supp.117.16.Peer-Reviewed Original ResearchDNA methylationGenome-wide DNA methylation analysisHeritable epigenetic informationPredominant epigenetic mechanismsAbstract DNA methylationDNA methylation analysisEpigenetic informationEpigenetic mechanismsGene promoterMethylation profilingGene expressionTCR triggeringMethylationMethylation analysisGenesHuman agingMemory CD8Cellular characteristicsT cellsCell subsetsIL-7Rα expressionImportant mechanismCellsPotential roleIL-7Rα
2012
1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
Kang SW, Kim SH, Lee N, Lee WW, Hwang KA, Shin MS, Lee SH, Kim WU, Kang I. 1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region. The Journal Of Immunology 2012, 188: 5276-5282. PMID: 22529297, PMCID: PMC3358577, DOI: 10.4049/jimmunol.1101211.Peer-Reviewed Original ResearchConceptsFoxp3 expressionT cellsVD receptorFOXP3 geneVD response elementsTreg cellsIL-2Foxp3-positive regulatory T cellsFoxp3 promoter activityHuman FOXP3 geneRegulatory T cellsImmune regulatory propertiesInhibitory functionHuman immune responseVitamin D response elementTCR triggeringD response elementImmune cellsImmune responseResponse elementUnique subsetRetinoic acidProliferation of targetsCellsExpression
2010
Regulating human Th17 cells via differential expression of IL-1 receptor (34.7)
Lee W, Kang S, Choi J, Lee S, Shah K, Eynon E, Flavell R, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor (34.7). The Journal Of Immunology 2010, 184: 34.7-34.7. DOI: 10.4049/jimmunol.184.supp.34.7.Peer-Reviewed Original ResearchIL-17 productionIL-1βT cellsCell differentiationMemory CD4Differential expressionIL-1RITCR triggeringT cell receptor triggeringIL-17IL-15Naive CD4IL-7IL-1 receptor expressionIL-1RI expressionT cell populationsIL-1R antagonistCytokine IL-7Gene expressionIL-1 receptorUmbilical cord bloodReceptor triggeringDistinct CD4Peripheral bloodCord bloodHuman IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34)
Lee H, Yu M, Lee D, Kang J, Hwang Y, Lee W, Kang I, Kim H. Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34). The Journal Of Immunology 2010, 184: 132.34-132.34. DOI: 10.4049/jimmunol.184.supp.132.34.Peer-Reviewed Original ResearchIL-2 productionMemory CD8T cellsCytokine productionIL-7Effector cytokine productionT cell subsetsAnergic T cellsPMA/ionomycin treatmentAnti-CD3 AbTCR triggeringEffector cytokinesAnergic phenotypeCell subsetsHuman CD8IL-2CD8Calcium fluxTCR stimulationIonomycin treatmentCell survival responseMAPK pathwayCellular characteristicsProliferationCells
2007
Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
Kim HR, Hwang KA, Kang I. Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway. The Journal Of Immunology 2007, 179: 6734-6740. PMID: 17982063, DOI: 10.4049/jimmunol.179.10.6734.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell ProliferationCell SurvivalEnzyme ActivationGene Expression RegulationHumansImmunologic MemoryInfectionsInterleukin-15Interleukin-2 Receptor beta SubunitInterleukin-7NeoplasmsPerforinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellReceptors, CCR7Receptors, Interleukin-17Signal TransductionConceptsIL-15T cellsPI3K/Akt pathwayAkt pathwayIL-7Memory T cell survivalProliferation of ILIL-15 signalingHuman peripheral bloodT cell survivalEffector cytokinesMemory CD8Peripheral bloodEffector functionsIL-7REnhanced gene expressionProliferative functionIndependent mechanismsILTCR triggeringCell survivalSuch cellsSurvivalTranscriptional factorsDual role