2020
Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases
Kahlenberg JM, Kang I. Advances in Disease Mechanisms and Translational Technologies: Clinicopathologic Significance of Inflammasome Activation in Autoimmune Diseases. Arthritis & Rheumatology 2020, 72: 386-395. PMID: 31562704, PMCID: PMC7050400, DOI: 10.1002/art.41127.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInflammasome activationRheumatic diseasesAutoimmune diseasesIL-18IL-1βClinicopathologic significanceProcaspase-1Damage-associated molecular patternsSystemic lupus erythematosusAdaptive immune pathwaysCrystal-induced arthropathiesCytokines IL-1βDevelopment of inflammationLocal inflammatory responseHost immune responsePrimary target organActive IL-1βActive caspase-1Inflammatory damageLupus erythematosusImmune toleranceRheumatoid arthritisSjögren's syndromePathogenic role
2012
Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1)
Kim H, Cho B, Sim J, Kim H, Yoo W, Kang I, Lee E. Characterization of Effector Memory CD8+ T cells in the Synovial fluid of Rheumatoid Arthritis (69.1). The Journal Of Immunology 2012, 188: 69.1-69.1. DOI: 10.4049/jimmunol.188.supp.69.1.Peer-Reviewed Original ResearchRheumatoid arthritisT cellsEM CD8Synovial fluidRA patientsMemory CD8Peripheral bloodMononuclear cellsHealthy controlsIL-10-producing CD8IL-4-producing CD8Synovial fluid mononuclear cellsProgression of RAPeripheral blood mononuclear cellsFluid mononuclear cellsEffector memory CD8T cell subsetsBlood mononuclear cellsKi-67 stainingDisease activitySuppressor cellsPD-1IL-15Cell subsetsLess perforin