2018
Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis
Lee H, Lee J, Kang I, Choi J. Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis. The Journal Of Immunology 2018, 200: 51.7-51.7. DOI: 10.4049/jimmunol.200.supp.51.7.Peer-Reviewed Original ResearchT cellsT cell antigen receptorIL-17AIL-23Memory CD4IL-1βImmune responseAutoimmune disease pathogenesisPro-inflammatory cytokinesIFN-γ expressionNaïve T cellsT cell activationAutoimmune neuroinflammationImmunopathological roleTh17 cellsAutoimmune pathogenesisBystander activationBystander CD4T lymphocytesIL-1Interleukin-1CD4Disease pathogenesisCell activationCell antigen receptor
2010
Regulating human Th17 cells via differential expression of IL-1 receptor (34.7)
Lee W, Kang S, Choi J, Lee S, Shah K, Eynon E, Flavell R, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor (34.7). The Journal Of Immunology 2010, 184: 34.7-34.7. DOI: 10.4049/jimmunol.184.supp.34.7.Peer-Reviewed Original ResearchIL-17 productionIL-1βT cellsCell differentiationMemory CD4Differential expressionIL-1RITCR triggeringT cell receptor triggeringIL-17IL-15Naive CD4IL-7IL-1 receptor expressionIL-1RI expressionT cell populationsIL-1R antagonistCytokine IL-7Gene expressionIL-1 receptorUmbilical cord bloodReceptor triggeringDistinct CD4Peripheral bloodCord bloodAge-associated alteration in naive and memory Th17 cell response in humans (85.8)
Lee J, Lee W, Kim S, Kang S, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans (85.8). The Journal Of Immunology 2010, 184: 85.8-85.8. DOI: 10.4049/jimmunol.184.supp.85.8.Peer-Reviewed Original ResearchRisk of infectionT cellsIL-17Naive CD4Peripheral bloodCell responsesIL-17-producing CD4IL-17-producing cellsFrequency of IFNTh17-polarizing cytokinesT cell immunityIFN-γ levelsT cell subsetsPMA/ionomycin stimulationAge-associated alterationsT cell receptorTh17 cellsCell immunityMemory CD4Tissue culture supernatantsAutoimmune diseasesCell subsetsMemory subsetsCD4Extracellular microorganisms
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response