Telomere Elongation in Dyskeratosis Congenita Induced Pluripotent Stem Cells.
Agarwal S, Loh Y, McLoughlin E, Huang J, Park I, Miller J, Huo H, Okuka M, dos Reis R, Loewer S, Keefe D, Goldman F, Klingelhutz A, Liu L, Daley G. Telomere Elongation in Dyskeratosis Congenita Induced Pluripotent Stem Cells. Blood 2009, 114: 497. DOI: 10.1182/blood.v114.22.497.497.Peer-Reviewed Original ResearchTelomerase RNA componentAutosomal dominant dyskeratosis congenitaPatient-specific iPS cellsInduced pluripotent stemIPS cellsDominant dyskeratosis congenitaSelf-renewal capacitySomatic cellsTERC locusDyskeratosis congenitaPluripotency-associated transcription factorsPrimary somatic cellsHallmarks of pluripotencyInduced pluripotent stem cellsTelomere lengthHuman iPS cellsHuman degenerative disordersPluripotent stem cellsTranscriptional silencingPluripotent stateTelomerase functionSteady-state levelsTranscription factorsRNA componentIPS linesHematopoietic Development from Human Induced Pluripotent Stem Cells
Lengerke C, Grauer M, Niebuhr NI, Riedt T, Kanz L, Park I, Daley GQ. Hematopoietic Development from Human Induced Pluripotent Stem Cells. Annals Of The New York Academy Of Sciences 2009, 1176: 219-227. PMID: 19796250, PMCID: PMC2849804, DOI: 10.1111/j.1749-6632.2009.04606.x.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsMouse embryonic stem cellsPluripotent stem cellsHematopoietic developmentInduced pluripotent stem cellsHuman induced pluripotent stem cellsHematopoietic stem cellsStem cellsDifferentiated somatic cellsHuman embryonic stem cellsHuman hematopoietic developmentStem cell linesGene expression dataIrradiated adult miceHox genesPluripotent stateBlood lineagesSomatic cellsEctopic expressionCombinatorial overexpressionExpression dataBlood formationIPS cellsColony activityMultilineage reconstitution