2024
Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials
Pulaski H, Mehta S, Manigat L, Kaufman S, Hou H, Nalbantoglu I, Zhang X, Curl E, Taliano R, Kim T, Torbenson M, Glickman J, Resnick M, Patel N, Taylor C, Bedossa P, Montalto M, Beck A, Wack K. Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials. The Journal Of Pathology Clinical Research 2024, 10: e12395. PMID: 39294925, PMCID: PMC11410674, DOI: 10.1002/2056-4538.12395.Peer-Reviewed Original ResearchConceptsClinical trialsAssessment of disease activityOverall percent agreementLiver biopsyDisease activityPathological assessmentWashout periodHistological assessmentEndpoint assessmentGold standardPercent agreementScoring systemExpert pathologistsSteatohepatitisAverage agreementDigital scoresPathologistsTrials
2022
Liver allograft findings of donation after cardiac death versus brain death in recipients with hepatitis C related cirrhosis: a matched histologic comparison
Byrnes K, Vachharajani N, Doyle MM, Nalbantoglu I. Liver allograft findings of donation after cardiac death versus brain death in recipients with hepatitis C related cirrhosis: a matched histologic comparison. Human Pathology 2022, 122: 25-31. PMID: 35085598, DOI: 10.1016/j.humpath.2022.01.005.Peer-Reviewed Original ResearchConceptsBiliary complicationsDCD casesLiver allograftsCardiac deathHistologic featuresBrain death (DBD) recipientsDCD liver allograftsPostoperative biliary complicationsBile duct injuryCold ischemia timeHepatitis C virusOrgan transplantation increasesBiliary alterationsDBD recipientsDCD allograftsDCD recipientsPortal edemaDuct injuryGraft survivalHepatitis CPortal inflammationOverall survivalTransplantation increasesLiver biopsyClinical outcomes
2021
Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan
Gibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. The Lancet Oncology 2021, 22: 306-307. PMID: 33662283, DOI: 10.1016/s1470-2045(20)30683-5.Peer-Reviewed Original ResearchGastric Xanthoma
Abu‐Alreesh S, Rosen D, Nalbantoglu I, Arbizu RA. Gastric Xanthoma. Journal Of Pediatric Gastroenterology And Nutrition 2021, 73: e26-e26. PMID: 33605661, DOI: 10.1097/mpg.0000000000003085.Peer-Reviewed Case Reports and Technical Notes
2020
Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft
González IA, Hartley CP, Nalbantoglu I. Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft. American Journal Of Clinical Pathology 2020, 155: 435-445. PMID: 33252121, DOI: 10.1093/ajcp/aqaa147.Peer-Reviewed Original ResearchConceptsDe novo AIHOrthotopic liver transplantDe novo autoimmune hepatitisAutoimmune hepatitisNovo autoimmune hepatitisRecurrent AIHRecurrent autoimmune hepatitisGraft survivalPresentation of AIHModerate portal inflammationOverall graft survivalAggressive clinical courseSubmassive necrosisLiver allograftsLiver transplantPortal inflammationSevere hepatitisAggressive treatmentAdvanced fibrosisClinical courseClinicopathologic characteristicsFemale predominanceSevere inflammationHepatitisPatientsPrimary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation
Aranake-Chrisinger J, Dassopoulos T, Yan Y, Nalbantoglu I. Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation. World Journal Of Gastroenterology 2020, 26: 4126-4139. PMID: 32821074, PMCID: PMC7403798, DOI: 10.3748/wjg.v26.i28.4126.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseOrthotopic liver transplantationPSC-IBD patientsUlcerative colitisCrohn's diseasePSC-UCLiver transplantationHistologic featuresLeft colonPSC-UC patientsPrimary sclerosing cholangitisRight-sided diseaseWarrants clinical attentionDifferent disease phenotypesIBD durationIBD patientsPSC patientsSclerosing cholangitisUC patientsActive inflammationRectal involvementBowel diseaseClinical featuresPSC diagnosisLess steroids
2019
Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine
Nalbantoglu I, Jain D. Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine. Seminars In Diagnostic Pathology 2019, 36: 389-394. PMID: 31395291, DOI: 10.1053/j.semdp.2019.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCryptogenic cirrhosisCC casesLiver diseaseUnknown etiologyMain histologic findingsPossible genetic counselingChronic liver diseaseWhole-exome sequencingCirrhosis casesPediatric patientsTransplant eligibilityHistologic findingsHistologic patternPotential etiologiesHistologic examinationHistologic characterizationGenetic testingEtiologyPatientsExome sequencingDiagnostic abilityGenetic counselingGenetic alterationsDiagnosisNew disorder
2018
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm
Joseph NM, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. The American Journal Of Surgical Pathology 2018, 42: 1201-1207. PMID: 29975248, DOI: 10.1097/pas.0000000000001110.Peer-Reviewed Original ResearchConceptsHepatic small vessel neoplasmVariant lesionsGNA14 mutationsVascular neoplasmLow-grade vascular neoplasmLow-grade neoplasmsVascular lesionsCavernous hemangiomaInfiltrative natureCytologic atypiaMolecular pathogenesisNeoplasmsPanel sequencingCopy number alterationsHotspot mutationsExome sequencingLesionsPathogenic mutationsSmall vesselsGNAQSame missense mutationNumber alterationsLiverMissense mutationsMutationsThe impact of diet‐induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury
Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, Finck BN. The impact of diet‐induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury. Liver Transplantation 2018, 24: 908-921. PMID: 29729104, PMCID: PMC6097916, DOI: 10.1002/lt.25189.Peer-Reviewed Original ResearchConceptsDiet-induced hepatic steatosisSteatotic liversHepatic steatosisReperfusion injuryLiver diseaseMicrovesicular steatosisMurine modelObesity-associated nonalcoholic fatty liver diseaseHepatic ischemia/reperfusion injuryEnd-stage liver diseaseIschemia/reperfusion injuryNonalcoholic fatty liver diseasePlasma alanine aminotransferase levelsAlanine aminotransferase levelsFatty liver diseaseCriteria donor organsInflammatory cytokine concentrationsPotential therapeutic approachHepatic IRISteatotic graftsLiver transplantationAminotransferase levelsCommon indicationNonalcoholic steatohepatitisOrgan failureUnique causes of esophageal inflammation: a histopathologic perspective
Gopal P, Gibson JA, Lisovsky M, Nalbantoglu I. Unique causes of esophageal inflammation: a histopathologic perspective. Annals Of The New York Academy Of Sciences 2018, 1434: 219-226. PMID: 29766506, DOI: 10.1111/nyas.13732.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEsophageal mucosal biopsiesEsophageal inflammationMucosal biopsiesMedication-induced esophageal injuryCause of esophagitisSymptoms of esophagitisHerpes simplex virusBacterial esophagitisInfectious esophagitisSloughing esophagitisEsophageal manifestationsReflux esophagitisEosinophilic esophagitisEsophageal injuryHistopathologic featuresPathologic diagnosisHistopathologic perspectiveCommon causeDermatologic diseasesEsophagitisSimplex virusUnique causeBiopsyInflammationCauseThe microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury
Zhang X, Patil D, Odze RD, Zhao L, Lisovsky M, Guindi M, Riddell R, Bellizzi A, Yantiss RK, Nalbantoglu I, Appelman HD. The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury. Annals Of The New York Academy Of Sciences 2018, 1434: 304-318. PMID: 29761508, DOI: 10.1111/nyas.13705.Peer-Reviewed Educational MaterialsConceptsSubmucosal nerve plexusNormal microscopic anatomyMicroscopic anatomyInlet patchSquamous liningSphincter mechanismNerve plexusSubmucosal glandsGastric mucosaGastrointestinal tractDistal aspectEsophageal wallIngested substancesEsophagusInjuryProximal partLymphatic vesselsPattern of reactionProtective functionStomachSpecific protective functionAnatomySpecific responsesSpecialized tissuesNerve
2017
Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study
Sun X, Chandar AK, Canto MI, Thota PN, Brock M, Shaheen NJ, Beer DG, Wang JS, Falk GW, Iyer PG, Abrams JA, Venkat-Ramani M, Veigl M, Miron A, Willis J, Patil DT, Nalbantoglu I, Guda K, Markowitz SD, Zhu X, Elston R, Chak A. Genomic regions associated with susceptibility to Barrett’s esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study. PLOS ONE 2017, 12: e0184962. PMID: 29073141, PMCID: PMC5657624, DOI: 10.1371/journal.pone.0184962.Peer-Reviewed Original ResearchDifferentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014.
Fraum TJ, Tsai R, Rohe E, Ludwig DR, Salter A, Nalbantoglu I, Heiken JP, Fowler KJ. Differentiation of Hepatocellular Carcinoma from Other Hepatic Malignancies in Patients at Risk: Diagnostic Performance of the Liver Imaging Reporting and Data System Version 2014. Radiology 2017, 286: 158-172. PMID: 28853673, DOI: 10.1148/radiol.2017170114.Peer-Reviewed Original ResearchConceptsNon-HCC malignanciesArterial phase hyperenhancementRim arterial phase hyperenhancementPositive predictive valueHepatocellular carcinomaPredictive valueData System (LI-RADS) version 2014Diagnostic performancePopulation of patientsHIPAA-compliant institutional review boardLiver Imaging ReportingLR-5 criteriaMalignant liver massesLI-RADS categoryFisher's exact testInstitutional review boardClinical followExtrahepatic malignanciesPathology findingsCommon findingLiver massExact testIndependent sample t-testMalignancyImaging ReportingHow does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency
Pehlivanoglu B, Hassoy H, Calle C, Dendooven A, Nalbantoglu I, Reshchikova L, Gul G, Doganavsargil B. How does it feel to be a pathology resident? Results of a survey on experiences and job satisfaction during pathology residency. Virchows Archiv 2017, 471: 413-422. PMID: 28624995, DOI: 10.1007/s00428-017-2167-2.Peer-Reviewed Original ResearchConceptsHealth care systemPatient managementClinicians/surgeonsPathology residencyCountry's health care systemCommon reasonGross examinationMedical teamExperienced pathologistsTraining programResidency training programsPathologyCare systemMolecular pathologyPathologistsResidency program directorsPhysical working conditionsWeb-based linkMost respondentsPathology traineesTumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Olsen S, Jin L, Fields RC, Yan Y, Nalbantoglu I. Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence. Human Pathology 2017, 68: 26-33. PMID: 28428104, DOI: 10.1016/j.humpath.2017.03.021.Peer-Reviewed Original ResearchConceptsIntestinal-type gastric adenocarcinomaHigher T stageIntestinal-type cancerGastric adenocarcinomaT stageNodal metastasisN stageLymph node statusSubset of patientsPrimary surgical excisionAmount of tumorCancer-related deathLikelihood of recurrenceDiffuse cancersBetter prognosisHistologic typePrognostic featuresSurgical excisionTumor buddingTumor characteristicsNode statusIntestinal tumorsClinical managementColorectal adenocarcinomaTumor grade
2016
Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, Zinselmeyer BH, Colombel JF. Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease. American Journal Of Pathology 2016, 186: 3066-3073. PMID: 27746181, PMCID: PMC5225286, DOI: 10.1016/j.ajpath.2016.07.026.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsMesenteric lymph nodesLymph nodesCrohn's diseaseLymphatic collecting vesselsInfection-induced tissue damageInnate lymphoid cellsChronic inflammatory stateImmune cell accessHuman intestinal diseasesMesenteric adipose tissueEarly pathological descriptionsAppropriate immunityInflammatory stateLymphoid organsPoor healingIntestinal diseaseLymphoid cellsPathological descriptionAdipose tissueB cellsAnatomical relationshipTissue damageCD specimensLymphatic remodelingCharacterization of Colorectal Cancer Development in Apcmin/+ Mice
Nalbantoglu I, Blanc V, Davidson NO. Characterization of Colorectal Cancer Development in Apcmin/+ Mice. Methods In Molecular Biology 2016, 1422: 309-327. PMID: 27246043, PMCID: PMC5061497, DOI: 10.1007/978-1-4939-3603-8_27.ChaptersConceptsDextran sulfate sodiumCancer developmentCommon pathologic lesionsBile acid supplementationExperimental colorectal cancerColorectal cancer developmentHigh-fat dietColon cancer developmentSulfate sodiumColorectal cancerFat dietAcid supplementationPathologic lesionsTherapeutic aspectsIntestinal neoplasiaC57BL/6J backgroundEnvironmental modifiersExperimental modelMiceExcellent experimental modelTissue processingNeoplasiaLesionsCancerGastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract
Pehlivanoğlu B, Doğanavşargil B, Sezak M, Nalbantoğlu İ, Korkmaz M. Gastrointestinal Parasitosis: Histopathological Insights to Rare But Intriguing Lesions of the Gastrointestinal Tract. Turkish Journal Of Pathology 2016, 32: 82-90. PMID: 27136106, DOI: 10.5146/tjpath.2015.01350.Peer-Reviewed Case Reports and Technical NotesConceptsEosinophils/hpfActive mucosal inflammationMild eosinophilic infiltrateMucosal architectural changesIncrease of eosinophilsInflammatory bowel diseasePresence of inflammationTaenia saginata infectionCharcot-Leyden crystalsF. hepaticaBowel obstructionNonspecific inflammationEosinophilic infiltrateEosinophilic infiltrationMucosal inflammationBowel diseaseMucosal changesStool testLymphoid aggregatesDefinitive diagnosisHistopathological insightsBiopsy specimensCeliac diseaseGranuloma formationIntriguing lesionsHepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential
Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Human Pathology 2016, 54: 143-151. PMID: 27090685, PMCID: PMC5242228, DOI: 10.1016/j.humpath.2016.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialDNA Mutational AnalysisFemaleGTP-Binding Protein alpha Subunits, Gq-G11Hemangioma, CavernousHemangiosarcomaHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsMaleMiddle AgedMutationNeoplasm GradingPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-mycTerminology as TopicTumor Suppressor Protein p53Vascular NeoplasmsYoung AdultConceptsHepatic small vessel neoplasmMalignant potentialCavernous hemangiomaVascular neoplasmImmunohistochemical stainsProliferative indexKi-67 proliferative indexTumour cell proliferative indexDisseminated intravascular coagulationKasabach-Merritt syndromePossible malignant potentialLow-grade tumorsUncertain malignant potentialRare vascular neoplasmCapture-based next-generation sequencingHistologic differential diagnosisCell proliferative indexC-myc stainingStrong p53Intravascular coagulationComplete resectionHepatic angiosarcomaDifferential diagnosisInfiltrative bordersAngiosarcoma
2015
Outcomes Using Grafts from Donors after Cardiac Death
Doyle MB, Collins K, Vachharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC. Outcomes Using Grafts from Donors after Cardiac Death. Journal Of The American College Of Surgeons 2015, 221: 142-152. PMID: 26095563, DOI: 10.1016/j.jamcollsurg.2015.03.053.Peer-Reviewed Original ResearchConceptsIschemic cholangiopathyPrimary nonfunctionRecipient ageLiver transplantationDonor graftsDCD donorsCardiac death liver graftsEnd-stage liver diseaseAdult liver transplantationDCD graft recipientsHepatic artery thrombosisAcute kidney injuryBrain-dead donorsLong-term outcomesWarm ischemia timeCold flushingDCD graftsDCD recipientsMedian ICUArtery thrombosisGraft survivalHospital stayKidney injuryRecipients of donationGraft recipients