2014
Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development
Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, Luo J, Chang SH, Hla T, Nalbantoglu I, Dharmarajan S, Davidson NO. Intestinal Epithelial HuR Modulates Distinct Pathways of Proliferation and Apoptosis and Attenuates Small Intestinal and Colonic Tumor Development. Cancer Research 2014, 74: 5322-5335. PMID: 25085247, PMCID: PMC4167566, DOI: 10.1158/0008-5472.can-14-0726.Peer-Reviewed Original ResearchConceptsTumor burdenSmall intestineFecal bile acid excretionAcute intestinal injuryColitis-associated cancerBile acid excretionBile acid metabolismColonic epithelial cellsAOM-DSSIntestinal deletionIntestinal injuryProapoptotic gene expressionIntestinal cancerCarcinogenesis protocolIntestinal expressionAcid excretionASBT expressionIntestinal tumorigenesisIntestinal growthVillus heightTransgenic modelGenetic deletionMiceExpression of transcriptsHuR gene
2013
Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice
Dharmarajan S, Newberry EP, Montenegro G, Nalbantoglu I, Davis VR, Clanahan MJ, Blanc V, Xie Y, Luo J, Fleshman JW, Kennedy S, Davidson NO. Liver Fatty Acid-Binding Protein (L-Fabp) Modifies Intestinal Fatty Acid Composition and Adenoma Formation in ApcMin/+ Mice. Cancer Prevention Research 2013, 6: 1026-1037. PMID: 23921281, PMCID: PMC3791217, DOI: 10.1158/1940-6207.capr-13-0120.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAnimalsCell ProliferationDietary FatsDinoprostoneFatty Acid-Binding ProteinsFatty AcidsFemaleGene DeletionGene Expression Regulation, NeoplasticGenotypeImmunohistochemistryIntestinal MucosaLipidsMiceMice, TransgenicPolymerase Chain ReactionRNA, MessengerSignal TransductionTime FactorsConceptsFatty acid traffickingDietary fat intakeFatty acid speciesFatty acid-binding proteinAcid-binding proteinFatty acid metabolismFat intakeIntestinal fatty acid metabolismIntestinal tumorigenesisCellular proliferationAcid metabolismFatty acid elongationNuclear hormone receptorsΒ-catenin translocationNuclear β-catenin translocationDiet-induced obesityHigh-grade dysplasiaLiver fatty acid-binding proteinIntestinal fatty acid-binding proteinIntestinal tumor formationImportant genetic modifiersSignificant reductionAcid speciesMetabolic compartmentalizationGenetic modifiers