2010
Panobinostat, a Novel Histone Deacetylase (HiDAC) Inhibitor Enhances the Anti-Tumor Activity of Bortezomib (BTZ) In Rituximab-Chemotherapy Sensitive and Resistant Lymphoma Cell Lines
Hernandez-Ilizaliturri F, Mavis C, Maraj I, Chisti M, Gibbs J, Czuczman M. Panobinostat, a Novel Histone Deacetylase (HiDAC) Inhibitor Enhances the Anti-Tumor Activity of Bortezomib (BTZ) In Rituximab-Chemotherapy Sensitive and Resistant Lymphoma Cell Lines. Blood 2010, 116: 3936. DOI: 10.1182/blood.v116.21.3936.3936.Peer-Reviewed Original ResearchCell linesBcl-xLBcl-2 family proteinsBcl-2 family membersLymphoma cell linesProteasome inhibitorsRegulation of BakAnti-tumor activityLymphoma cellsB-cell lymphomaCellular processesFamily proteinsWestern blotGene transcriptionPan-caspaseHistone deacetylase inhibitorsSingle agentTarget proteinsCaspase inhibitionMolecular eventsAlamar Blue reductionMcl-1Mitochondrial potentialATP synthesisHodgkin's lymphoma cell lines
2009
The DAC Inhibitor, LBH589, Is Highly Effective in Both Rituximab-Sensitive and Rituximab-Resistant Lymphomas and Enhances the Anti-Tumor Activity of Bortezomib, Other Chemotherapy Agents, and Anti-CD20 Monoclonal Antibodies.
Hernandez-Ilizaliturri F, Marvis C, Maraj I, Chisti M, Gibbs J, Czuczman M. The DAC Inhibitor, LBH589, Is Highly Effective in Both Rituximab-Sensitive and Rituximab-Resistant Lymphomas and Enhances the Anti-Tumor Activity of Bortezomib, Other Chemotherapy Agents, and Anti-CD20 Monoclonal Antibodies. Blood 2009, 114: 2715. DOI: 10.1182/blood.v114.22.2715.2715.Peer-Reviewed Original ResearchPatient-derived primary tumor cellsB-cell lymphomaPrimary tumor cellsChemotherapy agentsAnti-tumor activityMonoclonal antibodiesTumor cellsPolymerase chain reactionLymphoma cell linesCell linesAnti-CD20 Monoclonal AntibodyRoswell Park Cancer InstituteLarge B-cell lymphomaState Cancer CenterCD20 monoclonal antibodySignificant anti-tumor activitySequence of administrationQualitative polymerase chain reactionAnti-tumor effectsPotent treatment strategyNHL cell linesCombination of LBH589Primary lymphoma cellsResistant cell linesSensitive cell lines