2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2023
Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 346: 303-307. PMID: 37979626, DOI: 10.1016/j.jad.2023.11.041.Peer-Reviewed Original ResearchConceptsIndex traumaPTSD symptomsNational HealthPosttraumatic stress disorder (PTSD) symptomsVeterans StudyMilitary veteransTrauma-exposed populationsClinician-administered interviewU.S. military veteransConfirmatory factor analysisDSM-5 modelStrong significant associationTrauma exposureIntrusive symptomsDisorder symptomsCombat exposureHigh riskU.S. veteransDSM-5Significant associationSymptomsInterpersonal violenceFactor analysisPTSDScarce researchCorrelates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Korem N, Ben-Zion Z, Spiller T, Duek O, Harpaz-Rotem I, Pietrzak R. Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 339: 89-97. PMID: 37437721, DOI: 10.1016/j.jad.2023.07.036.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalEmotionsHumansRisk FactorsStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAvoidance copingTraumatic eventsU.S. military veteransEmotional stabilityNegative affect symptomsEmotional neglectSexual abuseAffect symptomsMilitary veteransAvoidant coping strategiesGreater emotional stabilityPhysical health outcomesPsychosocial risk factorsConsolidated memoryStress disorderCoping strategiesAdverse childhood experiencesStressful experiencesCopingVeterans StudyChildhood experiencesStrong feelingsNetwork analytic approachConscientiousness
2022
Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder
Duek O, Seidemann R, Pietrzak R, Harpaz-Rotem I. Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder. Journal Of Affective Disorders 2022, 324: 294-299. PMID: 36586605, DOI: 10.1016/j.jad.2022.12.105.Peer-Reviewed Original ResearchMeSH KeywordsAffectCognitionDepressive Disorder, MajorEmotionsHumansStress Disorders, Post-TraumaticConceptsEmotional numbing symptomsPosttraumatic stress disorderNumbing symptomsEmotional numbingStress disorderSymptom clustersTrauma-exposed individualsGreater PTSD severityMajor depressive disorderContext of traumaUnique variancePTSD symptomsPTSD phenotypePTSD severityDifferent symptom clustersWorse treatment outcomesDepressive disorderCore aspectsNumbingDistinct contributionsMDD symptomsDSM-IIIFunctional impairmentDisordersTreatment outcomesEmotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaEmotionsHumansMagnetic Resonance ImagingPainStress Disorders, Post-TraumaticVeteransConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptoms
2018
The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD
Sippel LM, Watkins LE, Pietrzak RH, Hoff R, Harpaz-Rotem I. The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD. Psychiatry 2018, 81: 271-282. PMID: 30015602, DOI: 10.1080/00332747.2017.1395313.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersDysphoric arousal symptomsPoor social connectednessArousal symptomsEmotional numbingSocial connectednessResidential treatmentPosttraumatic stress disorder (PTSD) symptomsSymptom clustersEmotional numbing symptomsMilitary veteransAnxious arousal symptomsFive-factor modelU.S. military veteransAnxious arousalDysphoric arousalNumbing symptomsInterpersonal functioningTrauma recoveryDisorder symptomsCase conceptualizationGreater distressMore distressPTSDSupportive people
2004
Revisiting Rapprochement in the Light of Contemporary Developmental Theories
Bergman A, Harpaz-Rotem I. Revisiting Rapprochement in the Light of Contemporary Developmental Theories. Journal Of The American Psychoanalytic Association 2004, 52: 555-569. PMID: 15222461, DOI: 10.1177/00030651040520020301.Peer-Reviewed Original Research