2024
Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrainCognitionCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMental DisordersMiddle AgedReproducibility of ResultsConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamples
2019
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study
Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionCognitive functioningStress disorderΕ4 carrier statusΕ4 carriersVeterans StudyCognitive dysfunctionAttention/concentrationGreater cognitive difficultiesLower cognitive functioningOlder U.S. veteransΕ4 allele carrier statusPerseverative errorsCognitive difficultiesReplication sampleCarrier statusCognitive functionImportance of assessingNational HealthCognitive declinePredictive effectApolipoprotein E gene polymorphismE gene polymorphismΕ4 allele carriers