2024
Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater odds
2023
Racial and ethnic mental health disparities in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study
Merians A, Gross G, Spoont M, Bellamy C, Harpaz-Rotem I, Pietrzak R. Racial and ethnic mental health disparities in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2023, 161: 71-76. PMID: 36905842, DOI: 10.1016/j.jpsychires.2023.03.005.Peer-Reviewed Original ResearchConceptsPsychiatric disordersWhite veteransNational HealthHispanic veteransMilitary veteransBlack veteransVeterans StudyLifetime major depressive disorderLifetime posttraumatic stress disorderHigh-risk subgroupsPopulation-based studyCurrent psychiatric disorderDrug use disordersMajor depressive disorderCommon psychiatric disordersEthnic differencesPopulation-based sampleCertain psychiatric disordersPopulation-based researchLower household incomeCurrent suicidal ideationPosttraumatic stress disorderRace/ethnicityU.S. military veteransMental health disparitiesEvaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Ben-Zion Z, Spiller T, Keynan J, Admon R, Levy I, Liberzon I, Shalev A, Hendler T, Harpaz-Rotem I. Evaluating the Evidence for Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. American Journal Of Psychiatry 2023, 180: 146-154. PMID: 36628514, PMCID: PMC9898083, DOI: 10.1176/appi.ajp.20220271.Peer-Reviewed Original ResearchConceptsPosttraumatic psychopathologyPsychiatric vulnerabilityGeneral hospital emergency departmentHospital emergency departmentRecent trauma survivorsAdditional replication studiesEmergency departmentObjective neural markersDifferent longitudinal patternsProspective symptomsMonths posttraumaAcute aftermathPsychiatric disordersEffective personalized treatmentTrauma exposureFunctional MRIPersonalized treatmentConsistent subgroupTreatment implicationsNeural activityAssessment 1Neural markersLongitudinal studyNeurobiological indicesDiagnostic methods
2021
Mental health and suicidal ideation in US military veterans with histories of COVID-19 infection
Na P, Tsai J, Harpaz-Rotem I, Pietrzak R. Mental health and suicidal ideation in US military veterans with histories of COVID-19 infection. BMJ Military Health 2021, 168: 15-19. PMID: 34035155, PMCID: PMC8154290, DOI: 10.1136/bmjmilitary-2021-001846.Peer-Reviewed Original ResearchConceptsStrong independent predictorUS military veteransSuicidal ideationIndependent predictorsCOVID-19COVID-related stressorsInternalising disordersPsychiatric conditionsProtective factorsMilitary veteransCOVID-19 infectionLogistic regression analysisPsychiatric symptom severityLower household incomeCurrent suicidal ideationSubstance use problemsProspective cohortMultivariable analysisTrauma burdenPositive screenUS veteransNational HealthPsychiatric symptomsPsychiatric disordersVeterans StudyThe hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Byrne SP, Fogle BM, Asch R, Esterlis I, Harpaz-Rotem I, Tsai J, Pietrzak RH. The hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2021, 291: 9-14. PMID: 34022553, DOI: 10.1016/j.jad.2021.04.088.Peer-Reviewed Original ResearchConceptsU.S. military veteransPsychiatric comorbidityPsychiatric disordersSuicidal ideationU.S. veteransAnxiety disordersComorbid psychiatric disordersMilitary veteransLifetime major depressionImportance of screeningPrevalent mental disordersSocial anxiety disorderMental health functioningCurrent suicidal ideationMeasures of functioningPosttraumatic stress disorderLifetime social anxiety disorderIncremental burdenMultivariable analysisPsychiatric morbidityNational HealthRepresentative sampleMajor depressionFunctional impairmentPsychiatric history
2017
Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities
Sippel LM, Allington CE, Pietrzak RH, Harpaz-Rotem I, Mayes LC, Olff M. Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities. Chronic Stress 2017, 1: 2470547016687996. PMID: 28649672, PMCID: PMC5482285, DOI: 10.1177/2470547016687996.Peer-Reviewed Original ResearchStress-related disordersStress-related psychiatric disordersNeurobiological mechanismsPosttraumatic stress disorderCritical moderating variablePsychiatric disordersStress disorderNeurohormone oxytocinClinical populationsEndogenous oxytocinModerating variableHeterogeneous findingsHealthy samplesOverview of evidenceSingle-dose studyMajor depressive disorderPromising findingsOxytocinDisordersDepressive disorderDosing schedulesNovel pharmacotherapiesMultidose studyReliable biomarkersTreatment opportunities
2016
POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS
Ruderman L, Ehrlich DB, Roy A, Pietrzak RH, Harpaz-Rotem I, Levy I. POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS. Depression And Anxiety 2016, 33: 606-613. PMID: 27000639, PMCID: PMC5247796, DOI: 10.1002/da.22494.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat veteransAmbiguity attitudesCombat exposureDecision-making taskTrauma-related symptomsAnxious arousal symptomsBehavioral economics techniquesUncertainty attitudesAnxious arousalNeural underpinningsTraditional diagnostic categoriesArousal symptomsStress disorderBehavioral levelBehavioral outcomesParticipants' choicesLoss domainBehavioral economicsPsychiatric symptomsVeteransAttitudesPsychiatric disordersUncertain outcomesUncertain gains
2013
Predominant typologies of psychopathology in the United States: A latent class analysis
El-Gabalawy R, Tsai J, Harpaz-Rotem I, Hoff R, Sareen J, Pietrzak RH. Predominant typologies of psychopathology in the United States: A latent class analysis. Journal Of Psychiatric Research 2013, 47: 1649-1657. PMID: 23978394, DOI: 10.1016/j.jpsychires.2013.07.028.Peer-Reviewed Original ResearchConceptsPopulation-based sampleSubstance use disordersAxis IU.S. adultsLatent class analysisUse disordersSuicide attemptsMental health-related qualityHealth-related qualityLifetime psychiatric disordersRates of moodAxis II disordersNational Epidemiologic SurveyPsychiatric comorbidityOverall high ratePsychiatric disordersEpidemiologic SurveyComorbid classesMental disordersClass analysisRelated conditionsAnxiety disordersBorderline/Personality disorderDisorders
2008
Impact of the Seeking Safety Program on Clinical Outcomes Among Homeless Female Veterans With Psychiatric Disorders
Desai RA, Harpaz-Rotem I, Najavits LM, Rosenheck RA. Impact of the Seeking Safety Program on Clinical Outcomes Among Homeless Female Veterans With Psychiatric Disorders. Psychiatric Services 2008, 59: 996-1003. PMID: 18757592, DOI: 10.1176/ps.2008.59.9.996.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase ManagementCognitive Behavioral TherapyCohort StudiesComorbidityFemaleFollow-Up StudiesHumansIll-Housed PersonsInterpersonal RelationsMaleMental DisordersMiddle AgedOutcome and Process Assessment, Health CareSafetySecondary PreventionSocial AdjustmentSocial SupportStress Disorders, Post-TraumaticSubstance-Related DisordersVeteransConceptsClinical outcomesSeeking SafetyHomeless women veteransSafety cohortHomeless female veteransWomen veteransFemale veteransMost clinical outcome measuresOne-year clinical outcomesVeterans Affairs Medical CenterClinical outcome measuresComorbid substance abuseIntensive case managementCognitive behavioral therapy interventionVeteran ProgramPosttraumatic stress disorderSubstance abuse problemsPostimplementation cohortGeneral symptomsLower followOutcome measuresMedical CenterPsychiatric disordersTherapy interventionArousal clusters