2022
Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measures
2020
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
Wang X, Xie H, Chen T, Cotton AS, Salminen LE, Logue MW, Clarke-Rubright EK, Wall J, Dennis EL, O’Leary B, Abdallah CG, Andrew E, Baugh LA, Bomyea J, Bruce SE, Bryant R, Choi K, Daniels JK, Davenport ND, Davidson RJ, DeBellis M, deRoon-Cassini T, Disner SG, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gomaa H, Gordon EM, Grupe D, Harpaz-Rotem I, Haswell CC, Herzog JI, Hofmann D, Hollifield M, Hosseini B, Hudson AR, Ipser J, Jahanshad N, Jovanovic T, Kaufman ML, King AP, Koch SBJ, Koerte IK, Korgaonkar MS, Krystal JH, Larson C, Lebois LAM, Levy I, Li G, Magnotta VA, Manthey A, May G, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Nitschke JB, Olff M, Olson EA, Peverill M, Phan K, Rashid FM, Ressler K, Rosso IM, Sambrook K, Schmahl C, Shenton ME, Sierk A, Simons JS, Simons RM, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Suarez-Jimenez B, Tamburrino M, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu Y, Zhu X, Thompson PM, Morey RA, Liberzon I. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis. Molecular Psychiatry 2020, 26: 4331-4343. PMID: 33288872, PMCID: PMC8180531, DOI: 10.1038/s41380-020-00967-1.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLateral orbitofrontal gyrusPTSD patientsCortical regionsComorbid depressionCortical volumeVolume abnormalitiesStress disorderSuperior parietal gyrusRegional cortical volumesSuperior temporal gyrusPrefrontal regulatory regionsCerebral cortexControl subjectsRight insularLimbic regionsParietal gyrusPosttraumatic stress symptom severityStress symptom severityDepression symptomsOrbitofrontal gyrusSymptom severityTemporal gyrusPatientsAbnormalities
2009
Duration of Pharmacotherapy with Long-Acting Injectable Risperidone in the Treatment of Schizophrenia
Mohamed S, Rosenheck R, Harpaz-Rotem I, Leslie D, Sernyak MJ. Duration of Pharmacotherapy with Long-Acting Injectable Risperidone in the Treatment of Schizophrenia. Psychiatric Quarterly 2009, 80: 241-249. PMID: 19768543, DOI: 10.1007/s11126-009-9111-9.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsInjectable risperidoneLong-Acting Injectable RisperidoneDuration of pharmacotherapyOral conventional antipsychoticsHalf of patientsMultivariable logistic regressionTreatment of schizophreniaDuration of treatmentProportional hazards modelOral antipsychoticsTreatment discontinuationOral medicationsReal-world practiceConventional antipsychoticsPatient characteristicsMedication adherenceAntipsychotic medicationVA patientsHazards modelAntipsychoticsMedicationsPatientsLogistic regressionRisperidoneTracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs
Harpaz-Rotem I, Rosenheck RA. Tracing the Flow of Knowledge: Geographic Variability in the Diffusion of Prazosin Use for the Treatment of Posttraumatic Stress Disorder Nationally in the Department of Veterans Affairs. JAMA Psychiatry 2009, 66: 417-421. PMID: 19349311, DOI: 10.1001/archgenpsychiatry.2008.536.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHealth care systemVeterans AffairsStress disorderSound Health Care SystemCare systemUse of prazosinPercentage of patientsTreatment of patientsTreatment of nightmaresPrazosin usePatient characteristicsNational health care systemMedical CenterMAIN OUTCOMEPrazosinPassive disseminationPatientsClinical practiceNew treatmentsPassive diffusionPrazosin hydrochlorideFiscal year 2004TreatmentPreliminary evidence