1975
The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain
Gross I, Rooney S, Warshaw J. The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain. Pediatric Research 1975, 9: 752-755. PMID: 648, DOI: 10.1203/00006450-197509000-00014.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFatty acid synthesisRabbit lungsFatty acid synthetaseAcetyl-CoA carboxylase activityAccelerated lung maturationCortisol-induced inhibitionHyaline membrane diseaseAdministration of cortisolFetal rabbit lungInfluence of cortisolFatty acid synthetase activityAcid synthesisFatty acid elongation activityAntenatal administrationNumber of inhibitoryMembrane diseaseRight lungLung maturationLung growthCortisol exposureElectron microscopic examinationFetal rabbitsFetal brainThe inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat
Gross I, Rooney S, Warshaw J. The inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat. Biochemical And Biophysical Research Communications 1975, 64: 59-63. PMID: 238512, DOI: 10.1016/0006-291x(75)90219-3.Peer-Reviewed Original ResearchConceptsPulmonary surfactant productionMicrosomal fatty acid elongationDietary deprivationRat lungFatty acid synthetaseDeprivation resultsAcute starvationInhibition of enzymesAcetyl-CoA carboxylaseSurfactant productionKnown inhibitionSignificant reductionFatty acid elongationFatty acidsInhibitionPhospholipid synthesisLung
1974
Fatty Acid Synthesis in Developing Brain
Gross I, Warshaw J. Fatty Acid Synthesis in Developing Brain. Neonatology 1974, 25: 365-375. PMID: 4156483, DOI: 10.1159/000240709.Peer-Reviewed Original ResearchConceptsFatty acid synthesisMaximal brain growthFatty acid synthetase activityRat brainBrain supernatant fractionPostnatal lifeSupernatant fractionBrain growthAcid synthesisAdult levelsFatty acid synthetaseAcetyl-CoA carboxylase activityBrainAcetyl-CoA carboxylaseSynthetase activityFourfold differenceActivityWeeks