2022
m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway
Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB. m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway. Science Advances 2022, 8: eabl5723. PMID: 35333576, PMCID: PMC8956260, DOI: 10.1126/sciadv.abl5723.Peer-Reviewed Original ResearchConceptsMucosal barrier dysfunctionInflammatory bowel diseaseBarrier dysfunctionColonic epithelial cellsColonic mucosal barrier dysfunctionEpithelial cellsStem cellsNF-κB pathwayPotential therapeutic targetEpithelial cell deathEpithelial cell homeostasisSevere colitisBowel diseaseColonic stem cellsTherapeutic targetMouse colonStem cell apoptosisDysfunctionMajor causeCell apoptosisImportant modulatorPathological processesAntiapoptotic pathwaysSpecific deletionCell homeostasis
2021
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche
Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021, 592: 606-610. PMID: 33658717, DOI: 10.1038/s41586-021-03283-y.Peer-Reviewed Original ResearchConceptsStem cell nicheR-spondin 1Intestinal stromal cellsCell nicheDistinct stem cell nichesIntestinal stem cell nicheStromal cellsIntestinal stem cellsStromal cell populationsTissue homeostasisReactive oxygen speciesIntestinal stemMolecular mechanismsAcute intestinal damageSpecific functionsPrimary cellular sourceStem cellsColon cryptsOxygen speciesCell populationsIntestinal injuryIntestinal damageNicheCellular sourceCells