Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway
Ge Y, Dou X, Chen P, Chen J, Dai M, Yao S, Lin Y. Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway. Molecular Neurobiology 2024, 1-13. PMID: 38886327, DOI: 10.1007/s12035-024-04287-1.Peer-Reviewed Original ResearchTreadmill exercisePost-strokeMorris water mazeTreadmill sessionsExercise mimeticsPost-stroke functional recoveryPost-ischemic strokePost-stroke recoveryTreadmillDentate gyrusRostral migratory streamEvaluate cognitive functionExerciseMiddle cerebral artery occlusionEnhanced neurogenesisCognitive functionModified neurological severity scoreSubventricular zoneSeverity scoreIschemic strokeSensorimotor functionControl groupFunctional recoveryExperimental groupIntraperitoneal injection of bromodeoxyuridineAbsence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice
Ge Y, Yang J, Chen J, Dai M, Dou X, Yao S, Yao C, Lin Y. Absence in CX3CR1 receptor signaling promotes post‐ischemic stroke cognitive function recovery through suppressed microglial pyroptosis in mice. CNS Neuroscience & Therapeutics 2024, 30: e14551. PMID: 38421089, PMCID: PMC10850801, DOI: 10.1111/cns.14551.Peer-Reviewed Original ResearchConceptsMorris water mazeNovel object recognition testObject recognition testCX3CR1<sup>-/-</sup> micePost-stroke cognitive impairmentRecognition testCX3CR1 receptorCognitive behavioral performanceWater mazeBehavioral performanceCognitive dysfunctionDouble-positive cellsCognitive functionSource of morbidityCognitive impairmentPositron emission tomographyEnhanced neurogenesisCognitive function recoveryCX3CR1 knockoutExpression of GSDMDMicroglial pyroptosisChronic phaseInfarct volumeCX3CR1Hippocampus