2017
A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall
Mei L, Chen J, Zong L, Zhu Y, Liang C, Jones R, Zhao H. A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall. Neurobiology Of Disease 2017, 108: 195-203. PMID: 28823936, PMCID: PMC5675824, DOI: 10.1016/j.nbd.2017.08.002.Peer-Reviewed Original ResearchConceptsCochlear lateral wallEndocochlear potentialHearing lossGap junctional functionDeafness mechanismLateral wallHeterozygous miceCx30 mutationsHair cell degenerationHomozygous knockout miceJunctional functionHeterozygous mouse modelGap junctionsOrgan of CortiSame gap junctional plaquesEP reductionFrequent causePathological changesMouse modelKnockout miceReceptor currentsCell degenerationNormal hearingHeterozygous mutationsMice
2001
Long-term natural culture of cochlear sensory epithelia of guinea pigs
Zhao H. Long-term natural culture of cochlear sensory epithelia of guinea pigs. Neuroscience Letters 2001, 315: 73-76. PMID: 11711218, DOI: 10.1016/s0304-3940(01)02357-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCochleaEpithelial CellsFluorescent Antibody TechniqueGuinea PigsMicroscopy, Phase-ContrastTimeConceptsCochlear sensory epitheliumCochlear sensory epithelial cellsSensory epithelial cellsSensory epitheliumHair cell markersCochlear cell lineIsolated cell clonesCochlear cellsEpithelial morphotypeGenetic manipulationProtein ZO-1Genetic studiesValuable cell sourceCulture cellsGuinea pigsCell linesEpithelial cellsZO-1Tight junctionsCell markersNatural cultureCell sourceCellsCell clonesCulture medium