2018
Knockout of Pannexin-1 Induces Hearing Loss
Chen J, Liang C, Zong L, Zhu Y, Zhao H. Knockout of Pannexin-1 Induces Hearing Loss. International Journal Of Molecular Sciences 2018, 19: 1332. PMID: 29710868, PMCID: PMC5983795, DOI: 10.3390/ijms19051332.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsHearing lossKO miceKO mouse lineMouse linesCochlear microphonicsAuditory brainstem response thresholdActive cochlear amplificationPanx1 KO miceAuditory function testsProduct otoacoustic emissionsKnockout mouse lineFunction testsNonsyndromic hearing lossABR thresholdHearing functionHigh incidenceRecent studiesGap junctional proteinReceptor currentsOtoacoustic emissionsMiceCochlear amplificationConsistent phenotypeResponse threshold
2008
ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance
Yu N, Zhao H. ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance. Pflügers Archiv - European Journal Of Physiology 2008, 457: 453-461. PMID: 18491132, PMCID: PMC5531446, DOI: 10.1007/s00424-008-0522-5.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsCalciumChelating AgentsEgtazic AcidElectric CapacitanceGuinea PigsHair Cells, Auditory, OuterMembrane PotentialsPatch-Clamp TechniquesPotassiumPurinergic P2 Receptor AntagonistsPyridoxal PhosphateReceptors, Purinergic P2Signal TransductionSodiumSuraminTime FactorsUridine TriphosphateConceptsP2X receptorsATP effectP2Y receptor agonistsMetabotropic purinergic receptorsActive cochlear amplifierEffect of ATPReceptor agonistHearing functionP2Y receptorsPurinergic receptorsDisulfonic acidImportant mediatorReceptorsCell functionOuter hair cell electromotilityHair cell electromotilityIonotropic purinergicCochlear amplifierOHC electromotilityTetraacetic acidATPAgonistsPurinergicVoltage dependenceSuramin
2004
Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate
Huang Z, Luo Y, Wu Z, Tao Z, Jones R, Zhao H. Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate. Journal Of Neurophysiology 2004, 93: 2053-2061. PMID: 15590729, DOI: 10.1152/jn.00959.2004.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsLong-term administrationOtotoxic mechanismsLong-term salicylate administrationAwake guinea pigsReversible hearing lossSalicylate-induced tinnitusActive cochlear mechanicsProduct otoacoustic emissionsInitial normal levelsDistortion productsSalicylate administrationSodium salicylateDaily injectionsSaline injectionHearing functionHearing lossCubic distortion productSingle injectionControl animalsOHC levelsCommon drugsSalicylate treatmentAcoustic emissionRate of recovery