2021
Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease
Mei L, Liu L, Chen K, Zhao H. Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease. Frontiers In Aging Neuroscience 2021, 13: 710317. PMID: 34588972, PMCID: PMC8473830, DOI: 10.3389/fnagi.2021.710317.Peer-Reviewed Original ResearchAuditory cortexCognitive declineEvent-related potentialsCortical potentialsCognitive activityCognitive changesNeural activationAD-related dementiaAD micePeak N2APP/PS1 AD miceAmyloid precursor proteinAlzheimer's diseasePeak P3AuditoryAuditory brainstem response recordingsNormal aging effectP1 peakCBA/CaJ micePeak P1Subdermal needle electrodesObjective biomarkersP3AECPCBA mice
2015
Pannexin 1 deficiency can induce hearing loss
Zhao H, Zhu Y, Liang C, Chen J. Pannexin 1 deficiency can induce hearing loss. Biochemical And Biophysical Research Communications 2015, 463: 143-147. PMID: 26002464, PMCID: PMC4464954, DOI: 10.1016/j.bbrc.2015.05.049.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsHearing lossAuditory brainstem response recordingsProgressive hearing lossProduct otoacoustic emissionsHigh incidenceCell degenerationOtoacoustic emissionsGap junction proteinAcoustic stimulationCell apoptotic pathwaysHair cellsResponse recordingsGene mutationsJunction proteinsExtensive expressionCochleaActive cochlear mechanicsGap junctionsApoptotic pathwayDeficiencyHearingCritical roleCochlear mechanics