2009
Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area
Zaveri HP, Pincus SM, Goncharova II, Duckrow RB, Spencer DD, Spencer SS. Localization-related epilepsy exhibits significant connectivity away from the seizure-onset area. Neuroreport 2009, 20: 891-895. PMID: 19424095, DOI: 10.1097/wnr.0b013e32832c78e0.Peer-Reviewed Original ResearchConceptsSeizure onset areaLocalization-related epilepsyControl of seizuresDiscrete cortical areasStandard clinical proceduresBeta frequency bandsUnselected patientsComplete resectionEpilepsy surgeryCortical areasFunctional connectivitySeizuresClinical proceduresEpilepsyIntracranial electroencephalogramSignificant connectivityResectionPatientsSurgery
2008
Neurometabolism in human epilepsy
Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OA, Spencer DD. Neurometabolism in human epilepsy. Epilepsia 2008, 49: 31-41. PMID: 18304254, PMCID: PMC3657747, DOI: 10.1111/j.1528-1167.2008.01508.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain DiseasesBrain MappingCarbon IsotopesDominance, CerebralElectrodes, ImplantedElectroencephalographyEpilepsyGamma-Aminobutyric AcidGlucoseHippocampusHumansLimbic SystemMagnetic Resonance SpectroscopyMetabolic DiseasesMicrodialysisMitochondrial DiseasesNeural PathwaysNeuronsPositron-Emission TomographyRatsSynaptic TransmissionConceptsNeurometabolic dysfunctionMagnetic resonance spectroscopic imagingHuman epilepsyEpileptic brainHippocampal resectionSclerotic hippocampusPathophysiologic aspectsEpileptogenic processMicrodialysis measuresExtracellular glutamateEpileptic dysfunctionEnergetic dysfunctionHuman studiesDysfunctionNeurotransmitter cyclingNoninvasive functional imagingProfound decreaseMitochondrial injuryBrain functionEpilepsyFunctional imagingMetabolic imagingBrainIntracranial EEGNeurometabolism
2007
Neocortical and Thalamic Spread of Amygdala Kindled Seizures
Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. Neocortical and Thalamic Spread of Amygdala Kindled Seizures. Epilepsia 2007, 48: 254-262. PMID: 17295618, DOI: 10.1111/j.1528-1167.2006.00934.x.Peer-Reviewed Original ResearchConceptsFrontal cortexMedial thalamusInterictal periodNervous systemSimultaneous field potential recordingsAmygdala-Kindled SeizuresResult of kindlingDevelopment of epilepsyNetwork plasticityField potential recordingsSeizure durationBehavioral seizuresMotor seizuresKindled SeizuresAmygdala kindlingEpilepsy modelSeizuresKindlingPotential recordingsNeocortical circuitsCortexBehavioral severityWeak stimulationThalamusPossible role