2018
Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram
Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia 2018, 59: 2075-2085. PMID: 30187919, DOI: 10.1111/epi.14559.Peer-Reviewed Original ResearchConceptsAED taperYale-New Haven HospitalAdult epilepsy patientsSeizure forecasting algorithmsElectrode contact pairsSeizure onset areaSeizure susceptibilityClinical recordsDrug taperElectrophysiological changesEpilepsy patientsIntracranial electroencephalographic dataMagnitude-squared coherenceModulatory activitySeizuresPatientsOnset areaPreseizurePostseizureProgressive desynchronizationIntracranial electroencephalogramDaysIctogenesisEffect of timeHospital
2015
A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms
Petroff OA, Spencer DD, Goncharova II, Zaveri HP. A comparison of the power spectral density of scalp EEG and subjacent electrocorticograms. Clinical Neurophysiology 2015, 127: 1108-1112. PMID: 26386645, DOI: 10.1016/j.clinph.2015.08.004.Peer-Reviewed Original Research
2014
The spatial and signal characteristics of physiologic high frequency oscillations
Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.Peer-Reviewed Original ResearchConceptsPhysiologic high-frequency oscillationsSeizure onsetEpileptic networkNon-rapid eye movement sleepComprehensive Epilepsy CenterMesial temporal structuresEye movement sleepHighest HFO ratesHigh-frequency oscillationsFirst seizureInvasive evaluationEpilepsy centersIntracranial evaluationMovement sleepPerirolandic regionEpileptiform dischargesParietooccipital regionOccipital lobeEpileptic sitesPatientsNonepileptic regionsPhysiologic eventsFast ripplesHFO ratesLonger duration
2013
Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice
Kanak DJ, Rose GM, Zaveri HP, Patrylo PR. Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice. PLOS ONE 2013, 8: e61364. PMID: 23593474, PMCID: PMC3620228, DOI: 10.1371/journal.pone.0061364.Peer-Reviewed Original ResearchConceptsCA3-CA1 circuitCA1 stratum pyramidaleSharp-wave ripplesAged miceStratum pyramidaleHippocampal slicesAge groupsCarbachol-induced gamma oscillationsSpontaneous sharp wavesCA1 stratum radiatumGamma oscillationsStratum oriensUnidentified neuronsAged neuronsStratum radiatumCA1 subregionNeuronal activityAdult miceSharp wavesUnit activityRipple oscillationsCollateral responsesMiceCA3Pyramidale
2012
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy
Perez EL, Lauritzen F, Wang Y, Lee TS, Kang D, Zaveri HP, Chaudhry FA, Ottersen OP, Bergersen LH, Eid T. Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy. Neurobiology Of Disease 2012, 47: 331-337. PMID: 22659305, PMCID: PMC3392431, DOI: 10.1016/j.nbd.2012.05.010.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyRecurrent seizuresConcentration of glutamateHippocampal formationLobe epilepsyExtracellular glutamateRefractory temporal lobe epilepsyEpileptogenic hippocampal formationExtracellular brain glutamateSubset of patientsSaline-treated ratsStart of infusionRatio of glutamateExcessive glutamateGlutamate excessBrain glutamateExtracellular brainAstrocytesExcessive releaseGS deficiencyRatsSeizuresGlutamateSeparate groupsEpilepsy