2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrain
2013
Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice
Kanak DJ, Rose GM, Zaveri HP, Patrylo PR. Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice. PLOS ONE 2013, 8: e61364. PMID: 23593474, PMCID: PMC3620228, DOI: 10.1371/journal.pone.0061364.Peer-Reviewed Original ResearchConceptsCA3-CA1 circuitCA1 stratum pyramidaleSharp-wave ripplesAged miceStratum pyramidaleHippocampal slicesAge groupsCarbachol-induced gamma oscillationsSpontaneous sharp wavesCA1 stratum radiatumGamma oscillationsStratum oriensUnidentified neuronsAged neuronsStratum radiatumCA1 subregionNeuronal activityAdult miceSharp wavesUnit activityRipple oscillationsCollateral responsesMiceCA3Pyramidale