2021
Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy
Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy. Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyAstroglial glutamine synthetaseTemporal lobe epilepsyLobe epilepsyIntractable mesial temporal lobe epilepsyAstrocytic glutamine synthetaseDepressive-like featuresPathogenesis of epilepsyType of epilepsyDiscrete brain regionsNeocortical epilepsyHippocampal neuronsEpilepsyBrain regionsGlutamate-ammonia ligaseLaboratory animalsPathogenesisPossible roleExperimental inhibitionGlutamine synthetaseEnzyme glutamine synthetaseDysfunctionSeizuresAstrocytesSyndrome
2018
2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain
Gruenbaum S, Dhaher R, Behar K, Zaveri H, Erfe M, Eid T. 2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain. Journal Of Clinical And Translational Science 2018, 2: 1-1. PMCID: PMC6808188, DOI: 10.1017/cts.2018.37.Peer-Reviewed Original ResearchIpsilateral hippocampusDentate gyrusAstroglial glutamine synthetaseMicrodialysis guide cannulaBlood-brain barrierImmune system dysfunctionRight dentate gyrusBilateral dentate gyrusL-type amino acid transporterBrief isoflurane anesthesiaArtificial extracellular fluidSignificant increaseGlutamine concentrationImportant therapeutic targetBilateral microdialysis probesAmino acid influxMethionine sulfoximineContralateral hippocampusLiver diseaseBrain ammoniaSynaptic glutamateBrain barrierSystem dysfunctionGuide cannulaIsoflurane anesthesia
2017
Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging
Wang H, Huang Y, Coman D, Munbodh R, Dhaher R, Zaveri HP, Hyder F, Eid T. Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging. Epilepsia 2017, 58: 824-834. PMID: 28378878, PMCID: PMC5429866, DOI: 10.1111/epi.13731.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyDiffusion tensor imagingTemporal lobe epilepsyFractional anisotropyLobe epilepsyAstroglial glutamine synthetaseEntorhinal-hippocampal areaEpileptogenic hippocampal formationNumerous brain regionsMultiple brain areasBrain diffusion tensor imagingLater time pointsInfused ratsEpileptogenic processCorpus callosumEpileptogenesisHippocampal formationBrain areasImaging biomarkersEarly identificationBrain regionsRatsTensor imagingFA changesTime points