2022
MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles
He L, Gao M, Pratt H, Weng Z, Struhl K. MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles. PLOS ONE 2022, 17: e0264799. PMID: 35482762, PMCID: PMC9049301, DOI: 10.1371/journal.pone.0264799.Peer-Reviewed Original Research
2021
YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
He L, Pratt H, Gao M, Wei F, Weng Z, Struhl K. YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. ELife 2021, 10: e67312. PMID: 34463254, PMCID: PMC8463077, DOI: 10.7554/elife.67312.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingCell Line, TumorCell Transformation, NeoplasticDatabases, GeneticFemaleGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsProtein BindingProtein Interaction Domains and MotifsSignal TransductionSTAT3 Transcription FactorTranscription Factor AP-1Transcription FactorsTranscriptional ActivationTranscriptional Coactivator with PDZ-Binding Motif ProteinsTriple Negative Breast NeoplasmsYAP-Signaling ProteinsConceptsTranscriptional co-activatorAP-1 proteinsAP-1Cellular transformationTarget siteNon-overlapping genesStimulated transcriptional activityAssociated with poor survival of breast cancer patientsPoor survival of breast cancer patientsSTAT3 motifTEAD proteinsSequence motifsGene classesWW domainEpigenetic switchTaz paralogTAZ-specificTranscriptional activityTranscription factorsTEADYAP/TAZSTAT3MotifTAZJunB
2018
Decoding the non-coding genome: Opportunities and challenges of genomic and epigenomic consortium data
Pratt H, Weng Z. Decoding the non-coding genome: Opportunities and challenges of genomic and epigenomic consortium data. Current Opinion In Systems Biology 2018, 11: 82-90. DOI: 10.1016/j.coisb.2018.09.002.Peer-Reviewed Original ResearchGenome-wide chromatin structureNext-generation sequencing dataCellular responses to stimuliFeatures of gene regulationUniform data processingNon-coding genomeTranscription factor bindingCell type differentiationIntegrated analysisGene expression changesSequence dataChromatin structureFactor bindingGene regulationOrganismal developmentTranscriptional activityExpression changesPhenotypic changesResponse to stimuliConsortium dataDisease mechanismsType differentiationComputational analysisInternational consortiumGenome