Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction
Zhao H, Sachla A, Helmann J. Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction. PLOS Genetics 2019, 15: e1008263. PMID: 31626625, PMCID: PMC6827917, DOI: 10.1371/journal.pgen.1008263.Peer-Reviewed Original ResearchMeSH KeywordsBacillus subtilisCell MembraneCell WallDNA DamageGene Expression Regulation, BacterialIntegrasesMembrane Transport ProteinsMutationOperonPromoter Regions, GeneticRegulonSigma FactorConceptsCell wall synthesisWall synthesisHydrophilic grooveMembrane protein insertaseMembrane protein overproductionIntegral membrane proteinsDNA damage responseSingle amino acid substitutionAmino acid substitutionsProtein translocaseSecretion stressFitness defectsOxidative stressDamage responseMembrane proteinsProtein overproductionRegulon inductionCell wallRegulonAcid substitutionsB. subtilisBacillus subtilisFunction mutationsCell deathCell growth