Deciphering the essentiality and function of the anti‐σM factors in Bacillus subtilis
Zhao H, Roistacher D, Helmann J. Deciphering the essentiality and function of the anti‐σM factors in Bacillus subtilis. Molecular Microbiology 2019, 112: 482-497. PMID: 30715747, PMCID: PMC6679829, DOI: 10.1111/mmi.14216.Peer-Reviewed Original ResearchConceptsAnti-sigma factorAlternative sigma factorSigma factorRNA polymerase core enzymeCell wall homeostasisStress conditionsSigma factor activitySevere growth defectBeta prime subunitCell wall synthesisAbility of mutationsDepletion strainCore enzymeTranscriptional landscapeSuppressor mutationsGrowth defectMerodiploid strainsRNA polymeraseWall synthesisMutations mapWall homeostasisAccessory proteinsPositive feedback loopBacillus subtilisFactor activity