2004
Obesity and the Risk of New-Onset Atrial Fibrillation
Wang T, Parise H, Levy D, D’Agostino R, Wolf P, Vasan R, Benjamin E. Obesity and the Risk of New-Onset Atrial Fibrillation. JAMA 2004, 292: 2471-2477. PMID: 15562125, DOI: 10.1001/jama.292.20.2471.Peer-Reviewed Original ResearchConceptsBody mass indexNew-onset atrial fibrillationEchocardiographic left atrial diameterLeft atrial diameterAtrial fibrillationRisk factorsAtrial diameterBMI categoriesMass indexAF riskCommunity-based observational cohortNormal body mass indexAge-adjusted incidence ratesInterim myocardial infarctionCardiovascular risk factorsVentricular diastolic dysfunctionBaseline atrial fibrillationClinical risk factorsModifiable risk factorsInfluence of obesityDiastolic dysfunctionAtrial dilatationAtrial dimensionClinical confoundersHazard ratioLocal Shear Stress and Brachial Artery Flow–Mediated Dilation
Mitchell G, Parise H, Vita J, Larson M, Warner E, Keaney J, Keyes M, Levy D, Vasan R, Benjamin E. Local Shear Stress and Brachial Artery Flow–Mediated Dilation. Hypertension 2004, 44: 134-139. PMID: 15249547, DOI: 10.1161/01.hyp.0000137305.77635.68.Peer-Reviewed Original ResearchConceptsHyperemic shear stressFlow-mediated dilationBrachial artery flow-mediated dilationArtery flow-mediated dilationRisk factorsPercent dilationBrachial arteryMultivariable analysisReactive hyperemiaEndothelium-dependent flow-mediated dilationCardiovascular disease risk factorsLipid medication useLocal endothelial dysfunctionStepwise multivariable analysisHormone replacement therapyMean arterial pressureDisease risk factorsBrachial artery flowPostischemic reactive hyperemiaBody mass indexSex-adjusted modelsFramingham Offspring StudyHigh-resolution ultrasoundArtery responsesEndothelial dysfunction
2003
Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality
Fox C, Vasan R, Parise H, Levy D, O’Donnell C, D’Agostino R, Benjamin E. Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality. Circulation 2003, 107: 1492-1496. PMID: 12654605, DOI: 10.1161/01.cir.0000058168.26163.bc.Peer-Reviewed Original ResearchConceptsMitral annular calcificationIncident CVDCVD deathCause deathAnnular calcificationHazard ratioPresence of MACIncident CVD eventsIncidence of CVDCardiovascular disease outcomesFramingham Heart Study subjectsMultivariable adjusted analysesSmall retrospective studiesCommunity-based cohortM-mode echocardiographyProportional hazards modelCardiovascular morbidityCVD eventsCVD morbidityCVD riskEchocardiographic assessmentAdjusted analysisRetrospective studyProspective dataIndependent associationImpact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function
Rutter M, Parise H, Benjamin E, Levy D, Larson M, Meigs J, Nesto R, Wilson P, Vasan R. Impact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function. Circulation 2003, 107: 448-454. PMID: 12551870, DOI: 10.1161/01.cir.0000045671.62860.98.Peer-Reviewed Original ResearchConceptsGlucose tolerance groupInsulin resistanceLV massHOMA-IRGlucose toleranceGlucose intoleranceTolerance groupAbnormal glucose tolerance groupNormal glucose tolerance groupFramingham Study subjectsAbnormal glucose toleranceGlucose tolerance categoriesLeft ventricular hypertrophyBody mass indexLarge community-based sampleLV wall thicknessCommunity-based sampleHeart failureVentricular hypertrophyLA sizeMass indexReferral biasMyocardial infarctionTolerance statusStudy subjects