2007
Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness
Levy D, Hwang S, Kayalar A, Benjamin E, Vasan R, Parise H, Larson M, Wang T, Selhub J, Jacques P, Vita J, Keyes M, Mitchell G. Associations of Plasma Natriuretic Peptide, Adrenomedullin, and Homocysteine Levels With Alterations in Arterial Stiffness. Circulation 2007, 115: 3079-3085. PMID: 17533184, DOI: 10.1161/circulationaha.106.652842.Peer-Reviewed Original ResearchConceptsN-terminal atrial natriuretic peptideCarotid-femoral pulse wave velocityB-type natriuretic peptidePulse wave velocityAtrial natriuretic peptideCarotid-radial pulse wave velocityCentral pulse pressurePlasma natriuretic peptidesNatriuretic peptideArterial stiffnessHomocysteine levelsPulse pressureFramingham Heart StudyHeart StudyPlasma N-terminal atrial natriuretic peptideDiastolic blood pressureMean arterial pressureCarotid pulse pressureArterial wall stiffnessForward pressure waveArterial pressureCentral systolicBlood pressureHomocysteine concentrationsCardiovascular diseasePulse Pressure and Risk of New-Onset Atrial Fibrillation
Mitchell G, Vasan R, Keyes M, Parise H, Wang T, Larson M, D’Agostino R, Kannel W, Levy D, Benjamin E. Pulse Pressure and Risk of New-Onset Atrial Fibrillation. JAMA 2007, 297: 709-715. PMID: 17312290, DOI: 10.1001/jama.297.7.709.Peer-Reviewed Original ResearchConceptsIncident atrial fibrillationMean arterial pressureAtrial fibrillationPulse pressureRisk factorsArterial pressureCommunity-based observational cohortNew-onset atrial fibrillationIncidence of AFAF incidence ratesClinical risk factorsModifiable risk factorsVentricular fractional shorteningFramingham Heart Study participantsImportant risk factorCommunity-based sampleAtrial dimensionObservational cohortAortic stiffnessConsiderable morbidityFractional shorteningSystolic pressureAF riskDiastolic pressureVentricular mass
2005
Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness
Mitchell G, Vita J, Larson M, Parise H, Keyes M, Warner E, Vasan R, Levy D, Benjamin E. Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness. Circulation 2005, 112: 3722-3728. PMID: 16330686, DOI: 10.1161/circulationaha.105.551168.Peer-Reviewed Original ResearchConceptsCarotid-femoral pulse wave velocityCardiovascular disease risk factorsDisease risk factorsBrachial pulse pressureMean arterial pressureAortic stiffnessAortic wall stiffnessRisk factorsArterial pressurePulse pressureBlood flowConventional cardiovascular disease risk factorsHyperemic forearm blood flowRisk factor-adjusted modelsFramingham Heart Study Offspring CohortAbnormal aortic stiffnessForearm blood flowBrachial artery diameterPeripheral microvascular functionForward pressure wave amplitudePulse wave velocitySmall artery structureHigh-resolution ultrasoundWall stiffnessMicrovascular reactivity
2004
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell G, Parise H, Benjamin E, Larson M, Keyes M, Vita J, Vasan R, Levy D. Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women. Hypertension 2004, 43: 1239-1245. PMID: 15123572, DOI: 10.1161/01.hyp.0000128420.01881.aa.Peer-Reviewed Original ResearchConceptsPulse wave velocityCarotid-femoral pulse wave velocityArterial stiffness gradientArterial stiffnessPulse pressureHigher carotid-femoral pulse wave velocityElevated central pulse pressureHigher mean arterial pressureCardiovascular disease risk factorsPeripheral pulse wave velocityFramingham Heart Study Offspring CohortClinical cardiovascular diseaseMean arterial pressurePeripheral arterial stiffnessCentral pulse pressureDisease risk factorsMultivariable linear regression modelsAge 50 yearsAge-related increaseArterial tonometryAortic stiffnessArterial pressureAugmentation indexHealthy menUnfavorable prognosis