2014
Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals
Fox HC, Morgan PT, Sinha R. Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals. Neuropsychopharmacology 2014, 39: 1527-1537. PMID: 24395021, PMCID: PMC3988558, DOI: 10.1038/npp.2014.1.Peer-Reviewed Original ResearchConceptsCocaine use disorderImagery conditionNegative emotionsDrug cravingUse disordersCocaine-dependent individualsCocaine-dependent malesCocaine-dependent menSex differencesGuanfacine's effectsDrug cuesImagery exposureNegative moodSystolic blood pressureStress arousalNicotine cravingAlcohol cravingCounterbalanced orderCravingCocaine cravingAnxietyCocaine addictionEmotionsRecovery time pointsGuanfacine
2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2012
Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine
Fox HC, Tuit KL, Sinha R. Stress system changes associated with marijuana dependence may increase craving for alcohol and cocaine. Human Psychopharmacology Clinical And Experimental 2012, 28: 40-53. PMID: 23280514, PMCID: PMC3660143, DOI: 10.1002/hup.2280.Peer-Reviewed Original ResearchConceptsAlcohol cravingCue-related cravingTreatment-seeking individualsStress-induced cortisolMeasures of cravingCue-induced anxietyMarijuana relapseMotivational processesImagery conditionAnxiety ratingsDrugs of abuseMarijuana dependenceEarly abstinenceCravingCocaine cravingMarijuana abuseAnxietyLittle researchCardiovascular outputRecovery time pointsCuesDependent groupInpatient treatmentAbuseHealthy controlsGuanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R. Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. Journal Of Psychopharmacology 2012, 26: 958-972. PMID: 22234929, PMCID: PMC3694403, DOI: 10.1177/0269881111430746.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdultCocaine-Related DisordersCombined Modality TherapyConnecticutDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleGuanfacineHumansImagery, PsychotherapyMagnetic Resonance ImagingMaleMiddle AgedNeuronsPilot ProjectsPrefrontal CortexStress, PsychologicalSubstance Withdrawal SyndromeConceptsCocaine-dependent individualsPrefrontal activityDrug cravingFunctional magnetic resonance imaging sessionDrug cue-induced cravingTreatment-seeking cocaine dependent individualsCue-induced drug cravingDependent individualsMagnetic resonance imaging sessionLateral prefrontal activityCue-induced cravingDrug cue exposureGuanfacine's effectsDrug cuesSubjective cravingImagery conditionPrefrontal activationCue exposurePhysiological arousalCognitive challengesBrain responsesAgonist guanfacineNicotine cravingGuanfacine groupCraving