2000
Hepatocyte Growth Factor Enhances MMP Activity in Human Endothelial Cells
Wang H, Keiser J. Hepatocyte Growth Factor Enhances MMP Activity in Human Endothelial Cells. Biochemical And Biophysical Research Communications 2000, 272: 900-905. PMID: 10860849, DOI: 10.1006/bbrc.2000.2852.Peer-Reviewed Original ResearchMeSH KeywordsCell LineCell MovementCollagenCoronary VesselsDermisDose-Response Relationship, DrugDrug CombinationsEndothelium, VascularEnzyme ActivationEnzyme InductionFlavonoidsHepatocyte Growth FactorHumansLamininMAP Kinase Signaling SystemMatrix Metalloproteinase 2Matrix Metalloproteinase InhibitorsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMitogen-Activated Protein KinasesMolecular WeightPhosphorylationProteoglycansProto-Oncogene Proteins c-metRNA, MessengerConceptsSF/HGFHepatocyte growth factorExtracellular matrixMAP kinase cascadeSignal transduction pathwaysScatter factorMT1-MMP synthesisMatrix metalloproteinasesGrowth factorHuman EC linesKinase cascadeTransduction pathwaysEC invasionHGF stimulationEndothelial cell productionHuman endothelial cellsMMP-2 activationArterial ECsMT1-MMPVessel stabilizationTube formationCurrent studyAngiogenic factorsEC linesMMP activity
1998
Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells
Wang H, Keiser J. Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells. Circulation Research 1998, 83: 832-840. PMID: 9776730, DOI: 10.1161/01.res.83.8.832.Peer-Reviewed Original ResearchMeSH KeywordsAortaBiocompatible MaterialsCell DivisionCell MovementCells, CulturedCollagenCollagenasesDrug CombinationsEndothelial Growth FactorsEndothelium, VascularEnzyme ActivationEnzyme-Linked Immunosorbent AssayExtracellular MatrixGelsGene Expression Regulation, EnzymologicHumansLamininLymphokinesMatrix Metalloproteinase 1Matrix Metalloproteinase 9Muscle, Smooth, VascularNeovascularization, PhysiologicPhosphorylationProteoglycansProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsHuman smooth muscle cellsKinase insert domain-containing receptorSmooth muscle cellsVascular smooth muscle cellsSMC migrationSignal transduction pathwaysVascular endothelial growth factorExtracellular matrix barriersMuscle cellsNorthern blot analysisMajor cell typesEffects of VEGFGrowth factorDomain-containing receptorTransduction pathwaysInsert domain-containing receptorFlt-1Endothelial cellsExpression of Membrane-Type Matrix Metalloproteinase in Rabbit Neointimal Tissue and Its Correlation with Matrix-Metalloproteinase-2 Activation
Wang H, Keiser J. Expression of Membrane-Type Matrix Metalloproteinase in Rabbit Neointimal Tissue and Its Correlation with Matrix-Metalloproteinase-2 Activation. Journal Of Vascular Research 1998, 35: 45-54. PMID: 9482695, DOI: 10.1159/000025564.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAortaBase SequenceBlotting, NorthernCells, CulturedDNA, ComplementaryEnzyme ActivationGelatinasesGene ExpressionHumansMaleMatrix Metalloproteinase 2Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMolecular Sequence DataMuscle, Smooth, VascularPolymerase Chain ReactionRabbitsRNA ProbesRNA, MessengerSequence HomologyConceptsBalloon catheter de-endothelializationMMP-2 activationArterial SMCsTemporal expression patternsMembrane-type matrix metalloproteinasesMembrane-type matrix metalloproteinaseNorthern blot analysisMatrix metalloproteinasesExtracellular matrix degradationRabbit cDNAMammalian cellsMT-MMP-1Matrix metalloproteinase-2 activationMT-MMP-1 expressionExpression patternsVascular neointimal formationSequence analysisMMP-2MMP cDNAPhenotypic alterationsCDNAPeak expressionRNA probesBlot analysisMatrix degradation