Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells
Wang H, Keiser J. Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells. Circulation Research 1998, 83: 832-840. PMID: 9776730, DOI: 10.1161/01.res.83.8.832.Peer-Reviewed Original ResearchMeSH KeywordsAortaBiocompatible MaterialsCell DivisionCell MovementCells, CulturedCollagenCollagenasesDrug CombinationsEndothelial Growth FactorsEndothelium, VascularEnzyme ActivationEnzyme-Linked Immunosorbent AssayExtracellular MatrixGelsGene Expression Regulation, EnzymologicHumansLamininLymphokinesMatrix Metalloproteinase 1Matrix Metalloproteinase 9Muscle, Smooth, VascularNeovascularization, PhysiologicPhosphorylationProteoglycansProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsHuman smooth muscle cellsKinase insert domain-containing receptorSmooth muscle cellsVascular smooth muscle cellsSMC migrationSignal transduction pathwaysVascular endothelial growth factorExtracellular matrix barriersMuscle cellsNorthern blot analysisMajor cell typesEffects of VEGFGrowth factorDomain-containing receptorTransduction pathwaysInsert domain-containing receptorFlt-1Endothelial cellsMolecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis
Wang H, Keiser J. Molecular characterization of rabbit CPP32 and its function in vascular smooth muscle cell apoptosis. American Journal Of Physiology 1998, 274: h1132-h1140. PMID: 9575916, DOI: 10.1152/ajpheart.1998.274.4.h1132.Peer-Reviewed Original ResearchConceptsCPP32 mRNASmooth muscle cellsDEVD-CHOSNP treatmentSignal transduction eventsCell death detection enzyme-linked immunosorbentDegradation of PARPApoptotic cell deathRabbit smooth muscle cellsVascular smooth muscle cell apoptosisCultured arterial smooth muscle cellsCaspase membersSmooth muscle cell apoptosisDNA fragmentation analysisMuscle cell apoptosisSubstrate recognitionTransduction eventsCPP32 proteinArterial smooth muscle cellsCultured smooth muscle cellsVascular smooth muscle cellsProtease familyDegenerate primersApoptosis pathwayCentral player