LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome
Wang H, Wang J, Zhao Y, Zhang X, Liu J, Zhang C, Haffty B, Verzi M, Zhang L, Gao N, Feng Z, Hu W. LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome. Cell Death & Disease 2020, 11: 588. PMID: 32719388, PMCID: PMC7385639, DOI: 10.1038/s41419-020-02790-6.Peer-Reviewed Original ResearchConceptsRadiation-induced GI syndromeLeukemia inhibitory factorIntestinal epitheliumIntestinal stem cellsLIF deficiencyGI syndromeGastrointestinal syndromeFunction of ISCsRadiation-induced gastrointestinal syndromeRecombinant leukemia inhibitory factorRecombinant LIFWild-type miceISC functionLifespan of miceAkt/GSK3βIntestinal epithelial regenerationIntestinal epithelial homeostasisStem cellsProlong survivalWT miceAdult intestinal epitheliumRadioprotective roleΒ-catenin activityCytokine essentialHigh doses