2022
The age-dependent association of risk factors with pancreatic cancer
Yuan C, Kim J, Wang QL, Lee AA, Babic A, Consortium P, Amundadottir LT, Ardanaz E, Arslan A, Beane-Freeman L, Bracci P, Bueno-de-Mesquita B, Du M, Gallinger S, Giles G, Goodman P, Katzke V, Klein A, Kooperberg C, Kraft P, Li D, Malats N, Marchand L, McCullough M, Milne R, Neoptolemos J, Perdomo S, Petersen G, Risch H, Shu X, Stolzenberg-Solomon R, Van Den Eeden S, Visvanathan K, White E, Wolpin B, Zheng W, Amundadottir L, Klein A, Li D, McCullough M, Petersen G, Risch H, Stolzenberg-Solomon R, Perez K, Ng K, Giovannucci E, Stampfer M, Kraft P, Wolpin B. The age-dependent association of risk factors with pancreatic cancer. Annals Of Oncology 2022, 33: 693-701. PMID: 35398288, PMCID: PMC9233063, DOI: 10.1016/j.annonc.2022.03.276.Peer-Reviewed Original ResearchConceptsPancreatic cancer casesRisk factorsPancreatic cancerProspective cohortMale sexBlack raceSEER programCancer casesPolygenic risk scoresRisk scoreProspective US cohort studyNon-modifiable risk factorsNon-O blood groupIncident pancreatic cancerUS cohort studyEnd Results ProgramPancreatic cancer riskAge-specific associationsEarly detection strategiesAge-dependent associationGenome-wide association studiesAdvanced diseaseCancer presentsCohort studyUS Surveillance
2015
Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk
Arem H, Yu K, Xiong X, Moy K, Freedman ND, Mayne ST, Albanes D, Arslan AA, Austin M, Bamlet WR, Beane-Freeman L, Bracci P, Canzian F, Cotterchio M, Duell EJ, Gallinger S, Giles GG, Goggins M, Goodman PJ, Hartge P, Hassan M, Helzlsouer K, Henderson B, Holly EA, Hoover R, Jacobs EJ, Kamineni A, Klein A, Klein E, Kolonel LN, Li D, Malats N, Männistö S, McCullough ML, Olson SH, Orlow I, Peters U, Petersen GM, Porta M, Severi G, Shu XO, Visvanathan K, White E, Yu H, Zeleniuch-Jacquotte A, Zheng W, Tobias GS, Maeder D, Brotzman M, Risch H, Sampson JN, Stolzenberg-Solomon RZ. Vitamin D Metabolic Pathway Genes and Pancreatic Cancer Risk. PLOS ONE 2015, 10: e0117574. PMID: 25799011, PMCID: PMC4370655, DOI: 10.1371/journal.pone.0117574.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskVitamin D statusCancer riskD statusSingle nucleotide polymorphismsVitamin DPancreatic cancerVitamin D metabolic pathway genesVitamin D metabolic pathwayVitamin D concentrationsUnconditional logistic regressionPancreatic cancer casesVitamin D.Cohort casesCUBN geneEffect modificationPancreatic adenocarcinomaCancer casesD concentrationsLogistic regressionProduct StatisticsRiskTop single nucleotide polymorphismsMultiple comparisonsCancer
2014
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
Neale RE, Clark PJ, Fawcett J, Fritschi L, Nagler BN, Risch HA, Walters RJ, Crawford WJ, Webb PM, Whiteman DC, Buchanan DD. Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer. Cancer Epidemiology 2014, 38: 576-582. PMID: 25201440, DOI: 10.1016/j.canep.2014.08.006.Peer-Reviewed Original ResearchConceptsPancreatic cancerWhite blood cell DNABlood cell DNAOdds ratioPresence of metastasesCancer-related deathPancreatic cancer casesHealthy unrelated controlsEarly diseaseCell DNALeading causeCancer casesWBC DNADNA repetitive elementsBlood collectionCancerConfidence intervalsUnrelated controlsMethylation scoreFurther studiesAssociationMarkersDeathPCR assaysQuantitative PCR assays
2013
Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4)
Bosetti C, Lucenteforte E, Bracci PM, Negri E, Neale RE, Risch HA, Olson SH, Gallinger S, Miller AB, Bueno-de-Mesquita HB, Talamini R, Polesel J, Ghadirian P, Baghurst PA, Zatonski W, Fontham E, Holly EA, Gao YT, Yu H, Kurtz RC, Cotterchio M, Maisonneuve P, Zeegers MP, Duell EJ, Boffetta P, La Vecchia C. Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case–Control Consortium (PanC4). Annals Of Oncology 2013, 24: 2903-2910. PMID: 23970016, PMCID: PMC3811904, DOI: 10.1093/annonc/mdt336.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskPancreatic Cancer Case-Control ConsortiumCancer riskPeptic ulcerOdds ratioInternational Pancreatic Cancer Case-Control ConsortiumMultivariable logistic regression modelHistory of gastrectomyHistory of ulcerCancer diagnosisH2-receptor antagonistsProton pump inhibitorsCase-control studyPancreatic cancer casesSummary odds ratiosLogistic regression modelsLarge collaborative studiesGastric surgeryPharmacological treatmentExcess riskCancer surveillancePancreatic cancerCancer casesGastrectomyUlcersThe Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH–AARP Study
Arem H, Reedy J, Sampson J, Jiao L, Hollenbeck AR, Risch H, Mayne ST, Stolzenberg-Solomon RZ. The Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH–AARP Study. Journal Of The National Cancer Institute 2013, 105: 1298-1305. PMID: 23949329, PMCID: PMC3760780, DOI: 10.1093/jnci/djt185.Peer-Reviewed Original ResearchConceptsHealthy Eating Index 2005Pancreatic cancer riskPancreatic cancerHazard ratioDietary guidelinesCancer riskExocrine pancreatic cancer casesOverweight/obese menCox proportional hazards regressionHealth-American AssociationP-interaction valuesRetired Persons DietFood frequency questionnaireNormal-weight menDietary pattern analysisBody mass indexProportional hazards regressionConfidence intervalsPancreatic cancer casesNIH-AARP studyFrequency questionnaireObese menMass indexHazards regressionWeight menDietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Arem H, Mayne ST, Sampson J, Risch H, Stolzenberg-Solomon RZ. Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Annals Of Epidemiology 2013, 23: 571-575. PMID: 23890797, PMCID: PMC3752990, DOI: 10.1016/j.annepidem.2013.06.006.Peer-Reviewed Original ResearchConceptsDietary fat intakePancreatic cancer riskOvarian Cancer Screening TrialCancer Screening TrialFat intakeCancer riskInverse associationPancreatic cancerScreening TrialCox proportional hazards regressionTotal fat intakeProportional hazards regressionObserved inverse associationPancreatic cancer casesHazards regressionCancer casesRisk associationUndetected diseasePossible reverse causationDietary changesIntakeReverse causationColorectalFat typeRiskABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis
Risch HA, Lu L, Wang J, Zhang W, Ni Q, Gao YT, Yu H. ABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis. American Journal Of Epidemiology 2013, 177: 1326-1337. PMID: 23652164, PMCID: PMC3732019, DOI: 10.1093/aje/kws458.Peer-Reviewed Original ResearchConceptsABO blood groupGroup BBlood groupPancreatic cancerNonendemic populationsGroup ASummary odds ratio (OR) estimatesGastric epithelial expressionPositive Helicobacter pyloriCagA-negative H. pylori strainsCytotoxin-associated genePancreatic cancer casesBlood group BOdds ratio estimatesH. pylori strainsPooled studiesCancer casesEpithelial expressionHigh riskB antigensGroup OSystematic reviewMeta-AnalysisHelicobacter pyloriPylori strainsFlavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort
Arem H, Bobe G, Sampson J, Subar AF, Park Y, Risch H, Hollenbeck A, Mayne ST, Stolzenberg-Solomon RZ. Flavonoid intake and risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study Cohort. British Journal Of Cancer 2013, 108: 1168-1172. PMID: 23299536, PMCID: PMC3619057, DOI: 10.1038/bjc.2012.584.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskHealth-AARP DietHealth Study cohortFlavonoid intakeCancer riskHazard ratioStudy cohortTotal flavonoid intakeDietary flavonoid intakeIntake of flavonoidsProspective National InstitutesConfidence intervalsPancreatic cancer casesCox proportional hazardsNational InstitutePancreatic cancer carcinogenesisLimited epidemiological studiesSmoking statusInverse associationPancreatic cancerCancer carcinogenesisCancer casesEpidemiological studiesProportional hazardsProtective role
2012
Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)
Duell EJ, Lucenteforte E, Olson SH, Bracci PM, Li D, Risch HA, Silverman DT, Ji BT, Gallinger S, Holly EA, Fontham EH, Maisonneuve P, Bueno-de-Mesquita HB, Ghadirian P, Kurtz RC, Ludwig E, Yu H, Lowenfels AB, Seminara D, Petersen GM, La Vecchia C, Boffetta P. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals Of Oncology 2012, 23: 2964-2970. PMID: 22767586, PMCID: PMC3477881, DOI: 10.1093/annonc/mds140.Peer-Reviewed Original ResearchConceptsInternational Pancreatic Cancer Case-Control ConsortiumPancreatic Cancer Case-Control ConsortiumPancreatic cancerOdds ratioStrong associationHistory of pancreatitisPopulation attributable fractionCase-control studyConfidence intervalsPancreatic cancer riskPooled odds ratioPancreatic cancer casesPrevious pancreatitisDuct obstructionPancreas cancerPooled analysisRisk factorsAttributable fractionCancer casesCancer riskPancreatitisCancerOld casesReverse causationDiagnosis