2023
Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry
Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G, Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. Cytopathology 2023, 34: 219-224. PMID: 36825365, DOI: 10.1111/cyt.13222.Peer-Reviewed Original ResearchGATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression
Wang M, Chen P, Cai G. GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. Human Pathology 2023, 135: 93-98. PMID: 36702357, DOI: 10.1016/j.humpath.2023.01.007.Peer-Reviewed Original ResearchConceptsLarge cell carcinomaPrimary lung carcinomaSarcomatoid carcinomaCell carcinomaNapsin ALung carcinomaGATA3 expressionTTF-1Non-small cell carcinomaNon-small cell lung carcinomaPrimary non-small cell lung carcinomasPrimary lung cancerSquamous cell carcinomaPanel of immunostainsCell lung carcinomaExpression of GATA3Whole-slide sectionsTMA casesAdenosquamous carcinomaTumor histologyHistopathologic featuresGATA3 stainingLung cancerP40 expressionTumor origin
2022
Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma
Wang M, Stendahl K, Cai G, Adeniran A, Harigopal M, Gilani SM. Evaluation of TRPS1 Expression in Pleural Effusion Cytology Specimens With Metastatic Breast Carcinoma. American Journal Of Clinical Pathology 2022, 158: 416-425. PMID: 35760555, DOI: 10.1093/ajcp/aqac066.Peer-Reviewed Original ResearchConceptsTrichorhinophalangeal syndrome type 1Breast originMetastatic carcinomaTRPS1 expressionBreast primaryBreast carcinomaPrimary siteMC casesMetastatic breast carcinomaSquamous cell carcinomaPleural effusion cytologySyndrome type 1Cell block materialStrong nuclear expressionEffusion cytology specimensCell carcinomaUrothelial carcinomaIHC panelMalignant melanomaLung adenocarcinomaIHC stainingPositive stainingCytology specimensCarcinomaEffusion cytology
2019
Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression
Malvi P, Janostiak R, Nagarajan A, Cai G, Wajapeyee N. Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression. PLOS Genetics 2019, 15: e1008439. PMID: 31589613, PMCID: PMC6797230, DOI: 10.1371/journal.pgen.1008439.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAdultAgedAnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDatasets as TopicDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGrowth Differentiation Factor 15HumansLungLung NeoplasmsMaleMiceMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvival AnalysisThymidine KinaseTranscription FactorsXenograft Model Antitumor AssaysConceptsShort hairpin RNALUAD cellsMetastatic attributesRho GTPase activityMAP kinase pathwayEctopic expressionGTPase activityTranscriptional overexpressionKinase pathwayKinase 1Cancer cell growthGenetic knockdownProfiling-based approachDifferentiation factor 15Hairpin RNALung adenocarcinoma patientsLung cancer growthCell growthLUAD therapyDownstream mediatorLUAD tumorsLUAD growthKey hallmarksReduced expressionDependent mannerMolecular Testing on Pleural Fluid Samples
Oh S, Ronaghi R, Cai G. Molecular Testing on Pleural Fluid Samples. Seminars In Respiratory And Critical Care Medicine 2019, 40: 340-346. PMID: 31525809, DOI: 10.1055/s-0039-1695702.Peer-Reviewed Original ResearchConceptsPleural fluid analysisPleural effusionFluid analysisMalignant diseasePleural fluidMalignant pleural effusionPleural fluid samplesRoutine thoracentesisNonmalignant diseasesCommon manifestationAppropriate stagingCytologic evaluationSignificant prognosticTherapeutic implicationsMolecular testingEffusionTreatment implicationsDiseaseFluid samplesSignificant numberLow sensitivityThoracentesisEtiologyStagingCancerEGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer
Hastings K, Yu HA, Wei W, Sanchez-Vega F, DeVeaux M, Choi J, Rizvi H, Lisberg A, Truini A, Lydon CA, Liu Z, Henick BS, Wurtz A, Cai G, Plodkowski AJ, Long NM, Halpenny DF, Killam J, Oliva I, Schultz N, Riely GJ, Arcila ME, Ladanyi M, Zelterman D, Herbst RS, Goldberg SB, Awad MM, Garon EB, Gettinger S, Hellmann MD, Politi K. EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer. Annals Of Oncology 2019, 30: 1311-1320. PMID: 31086949, PMCID: PMC6683857, DOI: 10.1093/annonc/mdz141.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmErbB ReceptorsFemaleGenetic HeterogeneityHumansLungLung NeoplasmsMaleMiddle AgedMutationProgrammed Cell Death 1 ReceptorProgression-Free SurvivalRetrospective StudiesTobacco SmokingConceptsEGFR-mutant tumorsMemorial Sloan-Kettering Cancer CenterYale Cancer CenterImmune checkpoint inhibitorsPD-L1 expressionImmune checkpoint blockadeTumor mutation burdenCancer CenterLung tumorsCheckpoint blockadeEGFR mutant lung tumorsMutant tumorsCheckpoint inhibitorsLung cancerMutation burdenImmune checkpoint blockade treatmentLow tumor mutation burdenDana-Farber Cancer InstituteEGFR wild-type lung cancersCheckpoint blockade treatmentCell lung cancerEGFR mutation subtypesSimilar smoking historyCell death 1Lung cancer cases
2013
Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma
Cai G, Wong R, Chhieng D, Levy GH, Gettinger SN, Herbst RS, Puchalski JT, Homer RJ, Hui P. Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma. Cancer Cytopathology 2013, 121: 500-507. PMID: 23495083, DOI: 10.1002/cncy.21288.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAnaplastic Lymphoma KinaseBiomarkers, TumorBone NeoplasmsCytodiagnosisDNA, NeoplasmErbB ReceptorsFeasibility StudiesFemaleGene RearrangementHumansIn Situ Hybridization, FluorescenceLiver NeoplasmsLung NeoplasmsMaleMiddle AgedMutationNeoplasm Recurrence, LocalPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsReal-Time Polymerase Chain ReactionReceptor Protein-Tyrosine KinasesSoft Tissue NeoplasmsYoung AdultConceptsALK gene rearrangementMetastatic lung adenocarcinomaEGFR mutationsKRAS mutationsMetastatic tumorsEpidermal growth factor receptorLung adenocarcinomaCytological specimensGene rearrangementsMolecular testsMolecular alterationsKirsten rat sarcoma viral oncogene homolog (KRAS) mutationsALK gene rearrangement analysisAnaplastic lymphoma kinase (ALK) gene rearrangementEGFR T790M mutationRat sarcoma viral oncogene homolog mutationsCases of lungT790M mutationImportant therapeutic implicationsFine needle aspiratesGene rearrangement analysisCell block materialGrowth factor receptorRecurrent lungRecurrent adenocarcinoma
2012
Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas
Levy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas. Diagnostic Cytopathology 2012, 41: 623-628. PMID: 22807461, DOI: 10.1002/dc.22893.Peer-Reviewed Original ResearchConceptsFine-needle aspirationPancreatic endocrine neoplasmsCytomorphologic featuresDiagnostic pitfallsEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationFine cytoplasmic vacuolesClinicopathologic featuresDiagnostic challengeEndocrine tumorsEndocrine neoplasmsSmall biopsiesAccurate diagnosisImmunocytochemical studyCytoplasmic vacuoles