2023
Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Sardana R, Abi‐Raad R, Adeniran A, Cai G. Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue. Cytopathology 2023, 34: 597-602. PMID: 37534757, DOI: 10.1111/cyt.13283.Peer-Reviewed Original ResearchMeSH KeywordsBiopsy, Fine-NeedleHumansImmunohistochemistryParathyroid HormoneParathyroid NeoplasmsRetrospective StudiesConceptsParathyroid tissueFine-needle aspirationPTH casesClinicopathological characteristicsCytomorphological featuresThyroid lesionsThinPrep slidesFine needle aspiration diagnosisNeck soft tissuePatients' clinicopathological characteristicsNeedle aspiration diagnosisNegative predictive valueClinical suspicionStudy cohortPathology databaseRetrospective studyDiagnostic challengeDifferential diagnosisInstitutional experienceNeedle aspirationCytological diagnosisFNA casesAspiration diagnosisPredictive valueAdjunct testDiagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry
Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G, Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. Cytopathology 2023, 34: 219-224. PMID: 36825365, DOI: 10.1111/cyt.13222.Peer-Reviewed Original Research
2022
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G. Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features. Cancer Cytopathology 2022, 131: 37-49. PMID: 36041224, PMCID: PMC9812877, DOI: 10.1002/cncy.22637.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBile Duct NeoplasmsBile DuctsChromatinHumansPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Retrospective StudiesConceptsIntraductal papillary neoplasmBile ductCytomorphologic featuresFine granular chromatinPapillary neoplasmVacuolated cytoplasmGranular chromatinCase of IPNBColumnar cellsComplex papillary architectureOriginal cytological diagnosisCommon bile ductCharacteristic cytomorphologic featuresHigh-grade dysplasiaMolecular featuresBackground mucinKRAS testingHepatic ductRetrospective studyAcute inflammationHistopathologic confirmationKRAS mutationsPapillary architecturePapillary clustersCytological diagnosisKi‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Wang X, Abi‐Raad R, Tang H, Cai G. Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification. Cancer Cytopathology 2022, 130: 974-982. PMID: 35876606, DOI: 10.1002/cncy.22630.Peer-Reviewed Original ResearchMeSH KeywordsBiopsy, Fine-NeedleGastrointestinal Stromal TumorsHumansKi-67 AntigenRetrospective StudiesRisk AssessmentConceptsGastrointestinal stromal tumorsKi-67 indexHigh mitotic rateLow mitotic rateCell block sectionsMitotic rateMitotic countRisk stratificationStromal tumorsSurgical specimensRisk of GISTCytology specimensMean Ki-67 indexPotential predictive valueBlock sectionsFine-needle aspiration specimensKi-67 immunostainLMR groupSurgical resectionDistal esophagusTumor sizeSpindle cellsGIST casesFNA specimensPredictive valueSignificance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review
Sun T, Zuo T, Hui P, Cai G. Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review. Cancer Cytopathology 2022, 130: 558-565. PMID: 35417072, DOI: 10.1002/cncy.22579.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary stenosisKRAS mutation testingKRAS mutational analysisKRAS mutationsBiliary stenosisBiliary ductsInstitutional review board approvalResults of cytologyPancreatic duct adenocarcinomaBiliary brushing cytologyReview board approvalCytological diagnostic categoriesRetrospective reviewBiliary stricturesDuct adenocarcinomaAbsolute riskCytology examinationDuct brushingsBiliary brushingsBrushing cytologyMalignant conditionsCytological diagnosisBoard approvalClinical practiceCytology specimens
2019
Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis
Ray AS, Li C, Murphy TE, Cai G, Araujo KLB, Bramley K, DeBiasi EM, Pisani MA, Cortopassi IO, Puchalski JT. Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis. The Annals Of Thoracic Surgery 2019, 109: 894-901. PMID: 31593653, PMCID: PMC9376016, DOI: 10.1016/j.athoracsur.2019.08.106.Peer-Reviewed Original ResearchConceptsStandard of careTransbronchial needle aspirationDiagnostic yieldHilar lymphadenopathyEndobronchial ultrasound transbronchial needle aspirationMediastinal/hilar lymphadenopathySolid organ malignanciesHigh diagnostic yieldGood tissue qualitySpecimen qualityForceps biopsyEBUS-TBNAParenchymal findingsPreprocedural imagingEndobronchial ultrasoundNeedle aspirationRetrospective analysisLymphadenopathyDiagnostic criteriaPatient basisDisease processTissue acquisitionPatientsClinical scenariosSarcoidosisEGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer
Hastings K, Yu HA, Wei W, Sanchez-Vega F, DeVeaux M, Choi J, Rizvi H, Lisberg A, Truini A, Lydon CA, Liu Z, Henick BS, Wurtz A, Cai G, Plodkowski AJ, Long NM, Halpenny DF, Killam J, Oliva I, Schultz N, Riely GJ, Arcila ME, Ladanyi M, Zelterman D, Herbst RS, Goldberg SB, Awad MM, Garon EB, Gettinger S, Hellmann MD, Politi K. EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer. Annals Of Oncology 2019, 30: 1311-1320. PMID: 31086949, PMCID: PMC6683857, DOI: 10.1093/annonc/mdz141.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmErbB ReceptorsFemaleGenetic HeterogeneityHumansLungLung NeoplasmsMaleMiddle AgedMutationProgrammed Cell Death 1 ReceptorProgression-Free SurvivalRetrospective StudiesTobacco SmokingConceptsEGFR-mutant tumorsMemorial Sloan-Kettering Cancer CenterYale Cancer CenterImmune checkpoint inhibitorsPD-L1 expressionImmune checkpoint blockadeTumor mutation burdenCancer CenterLung tumorsCheckpoint blockadeEGFR mutant lung tumorsMutant tumorsCheckpoint inhibitorsLung cancerMutation burdenImmune checkpoint blockade treatmentLow tumor mutation burdenDana-Farber Cancer InstituteEGFR wild-type lung cancersCheckpoint blockade treatmentCell lung cancerEGFR mutation subtypesSimilar smoking historyCell death 1Lung cancer cases
2013
Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up
Karunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up. Cancer Cytopathology 2013, 122: 23-32. PMID: 24127207, DOI: 10.1002/cncy.21350.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCohort StudiesDatabases, FactualEndoscopic Ultrasound-Guided Fine Needle AspirationFalse Negative ReactionsFemaleHumansImmunohistochemistryLung NeoplasmsLymph NodesMaleMediastinal NeoplasmsMiddle AgedRetrospective StudiesSensitivity and SpecificityConceptsEndobronchial ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationLymph nodesFine-needle aspirationDiagnostic yieldN1 lymph nodesN2 lymph nodesNegative cytologic diagnosisHilar lymph nodesMediastinal lymph nodesOverall diagnostic yieldChance of malignancyHigh diagnostic yieldNegative predictive valueFalse-negative diagnosesClinicopathologic findingsMediastinal lesionsLymphoid tissueInvasive modalitiesCytologic diagnosisPredictive valueUnsatisfactory casesGreater riskHistologicDiagnostic material
2012
Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis
Cai G, Mahooti S, Lipata FM, Chhieng D, Hui P. Diagnostic value of K‐ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis. Cancer Cytopathology 2012, 120: 313-318. PMID: 22367918, DOI: 10.1002/cncy.21188.Peer-Reviewed Original Research