KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity
Gupta R, Malvi P, Parajuli KR, Janostiak R, Bugide S, Cai G, Zhu LJ, Green MR, Wajapeyee N. KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 12341-12351. PMID: 32430335, PMCID: PMC7275752, DOI: 10.1073/pnas.2005156117.Peer-Reviewed Original ResearchConceptsGolgi complex integrityGolgi complex fragmentationKrüppel-like factor 7Complex integrityPDAC growthMAP kinase pathwayTumor suppressor p53Protein glycosylationPancreatic ductal adenocarcinomaKinase pathwayPancreatic cancer growthSuppressor p53PDAC tumor growthTumor growthISG expressionProtein 3Factor 7Cancer growthKLF7 expressionComplex fragmentationKnockdownPharmacologic activationGrowth factorCell culturesExpression