2009
Measuring Evolutionary Constraints Through the Dimensionality of the Phenotype: Adjusted Bootstrap Method to Estimate Rank of Phenotypic Covariance Matrices
Pavlicev M, Wagner G, Cheverud J. Measuring Evolutionary Constraints Through the Dimensionality of the Phenotype: Adjusted Bootstrap Method to Estimate Rank of Phenotypic Covariance Matrices. Evolutionary Biology 2009, 36: 339-353. DOI: 10.1007/s11692-009-9066-7.Peer-Reviewed Original ResearchEvolutionary constraintsCovariance matrixPhenotypic covariance matrixGenetic covariance matrixPhenotypic evolutionBootstrap methodPhenotypic variationGenetic variationPhenotype spaceLack of variationSelection responseFull rankMatrix rankRank estimatesNumber of variablesPhenotypeVariational dimensionsDimensionalityPhenotypicTraitsConstraintsMatrixVariationRankSample size
2001
The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change
STADLER B, STADLER P, WAGNER G, FONTANA W. The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change. Journal Of Theoretical Biology 2001, 213: 241-274. PMID: 11894994, DOI: 10.1006/jtbi.2001.2423.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapNeo-Darwinian modelGenotype-phenotype modelsPhenotypic innovationPhenotypic evolutionGenetic accessibilityEvolutionary trajectoriesEvolutionary changeNatural selectionPhenotypic charactersPhenotype spaceGenotype spaceRNA sequencesSecondary structureFitness landscapePossible phenotypesFitness considerationsRNA modelCharacter autonomyPhenotypeRecent computational workFoldingEvolutionRegionSequence