Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse
Leegant A, Zuckerwise LC, Downing K, Brouwer-Visser J, Zhu C, Cossio MJ, Strube F, Xie X, Banks E, Huang GS. Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse. Urogynecology 2015, 21: 53-58. PMID: 25185601, PMCID: PMC4344824, DOI: 10.1097/spv.0000000000000130.Peer-Reviewed Original ResearchConceptsPelvic organ prolapseTGF-β1 expressionMMP-9 expressionTGF-β1Uterosacral ligamentsMMP-9Vaginal hysterectomyOrgan prolapseSmooth muscleFibrous tissueGreater pelvic organ prolapseGrowth factor-β1 expressionInstitutional review board approvalMatrix metalloproteinase-9Review board approvalAge-related alterationsGrowth factor-β1Benign indicationsMetalloproteinase-9Clinical dataImmunohistochemical stainingBoard approvalTrichrome stainingFactor-β1Β1 expression