Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds
Amin ARMR, Karpowicz PA, Carey TE, Arbiser J, Nahta R, Chen ZG, Dong JT, Kucuk O, Khan GN, Huang GS, Mi S, Lee HY, Reichrath J, Honoki K, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bhakta D, Halicka D, Niccolai E, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Bilsland A, Shin DM. Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Seminars In Cancer Biology 2015, 35: s55-s77. PMID: 25749195, PMCID: PMC4561219, DOI: 10.1016/j.semcancer.2015.02.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCarcinogenesisCell ProliferationDNA-Binding ProteinsGrowth Differentiation Factor 15Hippo Signaling PathwayHumansKruppel-Like Transcription FactorsMolecular Targeted TherapyNeoplasmsNuclear ProteinsProtein Serine-Threonine KinasesPTEN PhosphohydrolaseRetinoblastoma ProteinSignal TransductionSomatomedinsTranscription FactorsTumor Suppressor Protein p53ConceptsInsulin-like growth factorGrowth signalingCancer cellsGrowth differentiation factor 15Cell growthSuppression of genesActivation of genesDifferentiation factor 15AT-rich interactive domain 1ASignaling processesRetinoblastoma proteinFactor 15Tensin homologRb pathwayClinical settingSignalingGrowth factorAdverse effectsDomain 1AMolecular targetsPotential targetPathwayHippoGenesImportant pathway